| http://purl.uniprot.org/citations/18218837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18218837 | http://www.w3.org/2000/01/rdf-schema#comment | "Dental pulp stem cells (DPSCs) are a unique precursor population isolated from postnatal human dental pulp and have the ability to regenerate a reparative dentin-like complex. Canonical Wnt signaling plays a critical role in tooth development and stem cell self-renewal through beta-catenin. In this study, the regulation of odontoblast-like differentiation of DPSCs by canonical Wnt signaling was examined. DPSCs were stably transduced with canonical Wnt-1 or the active form of beta-catenin, with retrovirus-mediated infection. Northern blot analysis found that Wnt-1 strongly induced the expression of matricellular protein osteopontin, and modestly enhanced the expression of type I collagen in DPSCs. Unexpectedly, Wnt-1 inhibited alkaline phosphatase (ALP) activity and the formation of mineralized nodules in DPSCs. Moreover, over-expression of beta-catenin was also sufficient to suppress the differentiation and mineralization of DPSCs. In conclusion, our results suggest that canonical Wnt signaling negatively regulates the odontoblast-like differentiation of DPSCs."xsd:string |
| http://purl.uniprot.org/citations/18218837 | http://purl.org/dc/terms/identifier | "doi:10.1177/154405910808700206"xsd:string |
| http://purl.uniprot.org/citations/18218837 | http://purl.uniprot.org/core/author | "Chang J."xsd:string |
| http://purl.uniprot.org/citations/18218837 | http://purl.uniprot.org/core/author | "Wang C.Y."xsd:string |
| http://purl.uniprot.org/citations/18218837 | http://purl.uniprot.org/core/author | "Scheller E.L."xsd:string |
| http://purl.uniprot.org/citations/18218837 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18218837 | http://purl.uniprot.org/core/name | "J Dent Res"xsd:string |
| http://purl.uniprot.org/citations/18218837 | http://purl.uniprot.org/core/pages | "126-130"xsd:string |
| http://purl.uniprot.org/citations/18218837 | http://purl.uniprot.org/core/title | "Wnt/beta-catenin inhibits dental pulp stem cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/18218837 | http://purl.uniprot.org/core/volume | "87"xsd:string |
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