| http://purl.uniprot.org/citations/18219097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18219097 | http://www.w3.org/2000/01/rdf-schema#comment | "The present study was designed to test whether common polymorphism G-50T within the promoter of human CYP2J2 gene is associated with increased risk of essential hypertension in a Russian population. We studied 576 unrelated subjects, including 295 patients with hypertension and 281 healthy subjects. Genotyping for polymorphism G-50T of the CYP2J2 gene was performed by polymerase chain reaction and restriction fragment length polymorphism techniques. The frequency of a -50T variant allele of CYP2J2 gene was significantly higher in patients with hypertension versus healthy controls (OR 4.03 95%CI 1.80-9.04 p=0.0004). The association of a -50GT genotype with hypertension remained significant after adjustment for age, gender and family history of hypertension by multivariate logistic regression (OR 4.78 95%CI 1.87-12.27 p=0.001). It has been found that OR for -50GT genotype x gender interaction (OR 4.48 95%CI 1.93-10.39 p=0.00048) was slightly higher than OR for -50GT genotype (OR 4.43 95%CI 1.91-10.29 p=0.00052), suggesting a weak effect of gender on the risk of hypertension in the heterozygous carriers of -50GT genotype. A family history of hypertension has no effect on the association between a -50GT genotype and hypertension. In present study we demonstrate for the first time that a CYP2J2*7 allele of the CYP2J2 gene is clearly associated with an increased risk of essential hypertension. Furthermore, this study highlights the importance of P-450 epoxygenase pathway of arachidonic acid metabolism in the pathogenesis of hypertensive disease."xsd:string |
| http://purl.uniprot.org/citations/18219097 | http://purl.org/dc/terms/identifier | "doi:10.1155/2008/626430"xsd:string |
| http://purl.uniprot.org/citations/18219097 | http://purl.uniprot.org/core/author | "Ivanov V.P."xsd:string |
| http://purl.uniprot.org/citations/18219097 | http://purl.uniprot.org/core/author | "Khoroshaya I.V."xsd:string |
| http://purl.uniprot.org/citations/18219097 | http://purl.uniprot.org/core/author | "Polonikov A.V."xsd:string |
| http://purl.uniprot.org/citations/18219097 | http://purl.uniprot.org/core/author | "Solodilova M.A."xsd:string |
| http://purl.uniprot.org/citations/18219097 | http://purl.uniprot.org/core/author | "Kozhuhov M.A."xsd:string |
| http://purl.uniprot.org/citations/18219097 | http://purl.uniprot.org/core/author | "Ivakin V.E."xsd:string |
| http://purl.uniprot.org/citations/18219097 | http://purl.uniprot.org/core/author | "Katargina L.N."xsd:string |
| http://purl.uniprot.org/citations/18219097 | http://purl.uniprot.org/core/author | "Kolesnikova O.E."xsd:string |
| http://purl.uniprot.org/citations/18219097 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18219097 | http://purl.uniprot.org/core/name | "Dis Markers"xsd:string |
| http://purl.uniprot.org/citations/18219097 | http://purl.uniprot.org/core/pages | "119-126"xsd:string |
| http://purl.uniprot.org/citations/18219097 | http://purl.uniprot.org/core/title | "A common polymorphism G-50T in cytochrome P450 2J2 gene is associated with increased risk of essential hypertension in a Russian population."xsd:string |
| http://purl.uniprot.org/citations/18219097 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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