| http://purl.uniprot.org/citations/18219120 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18219120 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18219120 | http://www.w3.org/2000/01/rdf-schema#comment | "SCO0332 protein is a putative TetR-family transcriptional regulator from Streptomyces coelicolor A3(2). The crystal structure of SCO0332 was determined at 2.25 A resolution by single-wavelength anomalous diffraction (SAD) phasing using the S atoms of the native protein. SCO0332 contains a helix-turn-helix (HTH) DNA-binding motif in its N-terminal region and forms a homodimer. The overall structure of SCO0332 shows significant similarity to other TetR-family regulators. A systematic evolution of ligands by exponential enrichment (SELEX) analysis indicated that SCO0332 has sequence-specific DNA-binding ability and determined the position of the operator element of SCO0332 on the chromosomal DNA of S. coelicolor. An electrophoretic mobility-shift assay (EMSA) showed that SCO0332 binds to the operator sequence upstream of the sco0330 gene, which encodes a putative short-chain oxidoreductase. These results suggest that SCO0332 is a transcriptional repressor that regulates sco0330 gene expression."xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.org/dc/terms/identifier | "doi:10.1107/S0907444907059835"xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.org/dc/terms/identifier | "doi:10.1107/s0907444907059835"xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/author | "Hayashi T."xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/author | "Hayashi T."xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/author | "Kondo K."xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/author | "Kondo K."xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/author | "Tamura T."xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/author | "Tamura T."xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/author | "Tanaka I."xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/author | "Tanaka I."xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/author | "Yao M."xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/author | "Yao M."xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/author | "Watanabe N."xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/author | "Watanabe N."xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/author | "Okada U."xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/author | "Okada U."xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/name | "Acta Crystallogr. D"xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/name | "Acta Crystallogr D Biol Crystallogr"xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/pages | "198-205"xsd:string |
| http://purl.uniprot.org/citations/18219120 | http://purl.uniprot.org/core/pages | "198-205"xsd:string |