| http://purl.uniprot.org/citations/18223652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18223652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18223652 | http://www.w3.org/2000/01/rdf-schema#comment | "The paracaspase MALT1 mediates T cell antigen receptor-induced signaling to the transcription factor NF-kappaB and is indispensable for T cell activation and proliferation. Enhanced expression of MALT1 or aberrant expression of a fusion protein of the apoptosis inhibitor API2 and MALT1 has been linked to mucosa-associated lymphoid tissue lymphoma. Despite the presence of a caspase-like domain, MALT1 proteolytic activity has not yet been demonstrated. Here we show that T cell antigen receptor stimulation induced recruitment of the NF-kappaB inhibitor A20 into a complex of MALT1 and the adaptor protein Bcl-10, leading to MALT1-mediated processing of A20. API2-MALT1 expression likewise resulted in cleavage of A20. MALT1 cleaved human A20 after arginine 439 and impaired its NF-kappaB-inhibitory function. Our studies identify A20 as a substrate of MALT1 and emphasize the importance of MALT1 proteolytic activity in the 'fine tuning' of T cell antigen receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1561"xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1561"xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Chen Z.J."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Chen Z.J."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Sun L."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Sun L."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Marynen P."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Marynen P."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Beyaert R."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Beyaert R."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Staal J."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Staal J."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Baens M."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Baens M."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Haegman M."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Haegman M."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Heyninck K."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Heyninck K."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Bekaert T."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Bekaert T."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Coornaert B."xsd:string |
| http://purl.uniprot.org/citations/18223652 | http://purl.uniprot.org/core/author | "Coornaert B."xsd:string |