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http://purl.uniprot.org/citations/18226226http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18226226http://www.w3.org/2000/01/rdf-schema#comment"

Background

Transforming Growth Factor-beta1 stimulated clone-22 (TSC-22) is assumed to act as a negative growth regulator and tumor suppressor. TSC-22 belongs to a family of putative transcription factors encoded by four distinct loci in mammals. Possible redundancy among the members of the TSC-22/Dip/Bun protein family complicates a genetic analysis. In Drosophila, all proteins homologous to the TSC-22/Dip/Bun family members are derived from a single locus called bunched (bun).

Results

We have identified bun in an unbiased genetic screen for growth regulators in Drosophila. Rather unexpectedly, bun mutations result in a growth deficit. Under standard conditions, only the long protein isoform BunA - but not the short isoforms BunB and BunC - is essential and affects growth. Whereas reducing bunA function diminishes cell number and cell size, overexpression of the short isoforms BunB and BunC antagonizes bunA function.

Conclusion

Our findings establish a growth-promoting function of Drosophila BunA. Since the published studies on mammalian systems have largely neglected the long TSC-22 protein version, we hypothesize that the long TSC-22 protein is a functional homolog of BunA in growth regulation, and that it is antagonized by the short TSC-22 protein."xsd:string
http://purl.uniprot.org/citations/18226226http://purl.org/dc/terms/identifier"doi:10.1186/1471-213x-8-10"xsd:string
http://purl.uniprot.org/citations/18226226http://purl.uniprot.org/core/author"Wu X."xsd:string
http://purl.uniprot.org/citations/18226226http://purl.uniprot.org/core/author"Raftery L.A."xsd:string
http://purl.uniprot.org/citations/18226226http://purl.uniprot.org/core/author"Hafen E."xsd:string
http://purl.uniprot.org/citations/18226226http://purl.uniprot.org/core/author"Oldham S."xsd:string
http://purl.uniprot.org/citations/18226226http://purl.uniprot.org/core/author"Rintelen F."xsd:string
http://purl.uniprot.org/citations/18226226http://purl.uniprot.org/core/author"Stocker H."xsd:string
http://purl.uniprot.org/citations/18226226http://purl.uniprot.org/core/author"Schutt C."xsd:string
http://purl.uniprot.org/citations/18226226http://purl.uniprot.org/core/author"Gluderer S."xsd:string
http://purl.uniprot.org/citations/18226226http://purl.uniprot.org/core/author"Sulzer A."xsd:string
http://purl.uniprot.org/citations/18226226http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18226226http://purl.uniprot.org/core/name"BMC Dev Biol"xsd:string
http://purl.uniprot.org/citations/18226226http://purl.uniprot.org/core/pages"10"xsd:string
http://purl.uniprot.org/citations/18226226http://purl.uniprot.org/core/title"Bunched, the Drosophila homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth."xsd:string
http://purl.uniprot.org/citations/18226226http://purl.uniprot.org/core/volume"8"xsd:string
http://purl.uniprot.org/citations/18226226http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18226226
http://purl.uniprot.org/citations/18226226http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18226226
http://purl.uniprot.org/uniprot/Q24522#attribution-CA3531D763D9EE1B46DBC547180CFBAFhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/18226226
http://purl.uniprot.org/uniprot/Q24523#attribution-CA3531D763D9EE1B46DBC547180CFBAFhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/18226226
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http://purl.uniprot.org/uniprot/#_Q24523-mappedCitation-18226226http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18226226
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