DESCRIBE <http://purl.uniprot.org/citations/18227995>

Subject	Predicate	Object
http://purl.uniprot.org/citations/18227995	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18227995	http://www.w3.org/2000/01/rdf-schema#comment	" Aims/hypothesis A genome-wide association study recently identified an association between common variants, rs1535435 and rs9494266, in the AHI1 gene and type 2 diabetes. The aim of the present study was to investigate the putative association between these polymorphisms and type 2 diabetes or type 2 diabetes-related metabolic traits in Danish individuals. Methods The previously associated polymorphisms were genotyped in the population-based Inter99 cohort (n=6162), the Danish ADDITION study (n=8428), a population-based sample of young healthy participants (n=377) and in additional type 2 diabetes (n=2107) and glucose-tolerant participants (n=483) using Taqman allelic discrimination. The case-control study involved 4,104 type 2 diabetic patients and 5,050 glucose-tolerant control participants. Type 2 diabetes-related traits were investigated in 17,521 individuals. Results rs1535435 and rs9494266 were not associated with type 2 diabetes. Odds ratios (OR) were OR(add) 1.0 (95% C.I. 0.9-1.2; p(add)=0.7) and OR(add) 1.1 (0.9-1.2; p(add)=0.4), respectively, a finding supported by meta-analyses: OR(add) 1.0 (0.9-1.1; p(add)=0.6) and OR(add) 1.0 (0.9-1.1; p(add)=0.6), respectively. Neither rs1535435 nor rs9494266 were consistently associated with any of the tested type 2 diabetes-related metabolic traits. Conclusions/interpretation Data from large samples of Danish individuals do not support a role for AHI1 rs1535435 nor rs9494266 as major type 2 diabetes variants. This study highlights the importance of independent and well-powered replication studies of the recent genome-wide association scans before a locus is robustly validated as being associated with type 2 diabetes."xsd:string
http://purl.uniprot.org/citations/18227995	http://purl.org/dc/terms/identifier	"doi:10.1007/s00125-008-0925-z"xsd:string
http://purl.uniprot.org/citations/18227995	http://purl.uniprot.org/core/author	"Hansen T."xsd:string
http://purl.uniprot.org/citations/18227995	http://purl.uniprot.org/core/author	"Jorgensen T."xsd:string
http://purl.uniprot.org/citations/18227995	http://purl.uniprot.org/core/author	"Pedersen O."xsd:string
http://purl.uniprot.org/citations/18227995	http://purl.uniprot.org/core/author	"Andersen G."xsd:string
http://purl.uniprot.org/citations/18227995	http://purl.uniprot.org/core/author	"Borch-Johnsen K."xsd:string
http://purl.uniprot.org/citations/18227995	http://purl.uniprot.org/core/author	"Holmkvist J."xsd:string
http://purl.uniprot.org/citations/18227995	http://purl.uniprot.org/core/author	"Lauritzen T."xsd:string
http://purl.uniprot.org/citations/18227995	http://purl.uniprot.org/core/author	"Sandbaek A."xsd:string
http://purl.uniprot.org/citations/18227995	http://purl.uniprot.org/core/author	"Wegner L."xsd:string
http://purl.uniprot.org/citations/18227995	http://purl.uniprot.org/core/author	"Anthonsen S."xsd:string
http://purl.uniprot.org/citations/18227995	http://purl.uniprot.org/core/date	"2008"xsd:gYear
http://purl.uniprot.org/citations/18227995	http://purl.uniprot.org/core/name	"Diabetologia"xsd:string
http://purl.uniprot.org/citations/18227995	http://purl.uniprot.org/core/pages	"609-614"xsd:string
http://purl.uniprot.org/citations/18227995	http://purl.uniprot.org/core/title	"Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association result."xsd:string
http://purl.uniprot.org/citations/18227995	http://purl.uniprot.org/core/volume	"51"xsd:string
http://purl.uniprot.org/citations/18227995	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/18227995
http://purl.uniprot.org/citations/18227995	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/18227995
http://purl.uniprot.org/uniprot/#_A0A7P0T7Z8-mappedCitation-18227995	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18227995
http://purl.uniprot.org/uniprot/#_Q9NXT1-mappedCitation-18227995	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18227995
http://purl.uniprot.org/uniprot/#_Q9H803-mappedCitation-18227995	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18227995
http://purl.uniprot.org/uniprot/#_Q8N157-mappedCitation-18227995	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18227995
http://purl.uniprot.org/uniprot/#_Q8NER0-mappedCitation-18227995	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18227995