| http://purl.uniprot.org/citations/18230613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18230613 | http://www.w3.org/2000/01/rdf-schema#comment | "Endothelial dysfunction plays a central role in diabetic vascular disease, but its molecular bases are not completely defined. We showed previously that the actin-binding protein proflin-1 was increased in the diabetic endothelium and that attenuated expression of profilin-1 protected against atherosclerosis. Also 7-ketocholesterol up-regulated profilin-1 in endothelial cells via transcriptional mechanisms. The present study addressed the pathways responsible for profilin-1 gene expression in 7-ketocholesterol-stimulated endothelial cells and in the diabetic aorta. In luciferase reporter assays, the response to 7-ketocholesterol within the 5'-flanking region of profilin-1 was dependent on a single STAT response element. In aortic endothelial cells, 7-ketocholesterol enhanced STAT3 activation, which required JAK2 and tyrosine 394 phosphorylation of oxysterol-binding protein-1. These changes were recapitulated in the aorta of diabetic rats. Also 7-ketocholesterol in cultured endothelial cells and diabetes in the aorta elicited the recruitment of STAT3 and relevant coregulatory factors to the oxysterol-responsive region of the profilin-1 promoter. These events were required for profilin-1 up-regulation. These studies identify a previously unrecognized oxysterol-binding protein-mediated mode of activation of STAT3 that controls the expression of the proatherogenic protein profilin-1 in response to 7-ketocholesterol and the diabetic milieu."xsd:string |
| http://purl.uniprot.org/citations/18230613 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m710092200"xsd:string |
| http://purl.uniprot.org/citations/18230613 | http://purl.uniprot.org/core/author | "Kazlauskas A."xsd:string |
| http://purl.uniprot.org/citations/18230613 | http://purl.uniprot.org/core/author | "Romeo G.R."xsd:string |
| http://purl.uniprot.org/citations/18230613 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18230613 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18230613 | http://purl.uniprot.org/core/pages | "9595-9605"xsd:string |
| http://purl.uniprot.org/citations/18230613 | http://purl.uniprot.org/core/title | "Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1."xsd:string |
| http://purl.uniprot.org/citations/18230613 | http://purl.uniprot.org/core/volume | "283"xsd:string |
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