| http://purl.uniprot.org/citations/18234692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18234692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18234692 | http://www.w3.org/2000/01/rdf-schema#comment | "Signal transducers and activators of transcription (STATs) mediate cell proliferation, differentiation and survival in immune responses, hematopoiesis, neurogenesis and other biological processes. STAT3, for example, is involved in the epithelial-mesenchymal transition during gastrulation, organogenesis, wound healing and cancer progression. STAT activity is regulated by a variety of mechanisms, including nuclear translocation. To clarify the molecular mechanisms underlying the regulation of STAT activity, we performed yeast two-hybrid screening. Here, we identified binder of ADP-ribosylation factor-like two (BART) as a novel STAT-binding partner. Importantly, we showed that BART is essential for the transcriptional activity and nuclear retention of STAT3. Furthermore, an effector of BART, ADP-ribosylation factor-like 2 (ARL2) was also involved in nuclear retention of STAT3. These results indicate that BART plays an essential role in the nuclear retention of STAT3 through interaction with ARL2."xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxm154"xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxm154"xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/author | "Sato N."xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/author | "Sato N."xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/author | "Matsuda T."xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/author | "Matsuda T."xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/author | "Ikeda O."xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/author | "Ikeda O."xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/author | "Muromoto R."xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/author | "Muromoto R."xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/author | "Sekine Y."xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/author | "Sekine Y."xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/author | "Okayama T."xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/author | "Okayama T."xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/author | "Imoto S."xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/author | "Imoto S."xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/name | "Int. Immunol."xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/name | "Int. Immunol."xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/pages | "395-403"xsd:string |
| http://purl.uniprot.org/citations/18234692 | http://purl.uniprot.org/core/pages | "395-403"xsd:string |