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http://purl.uniprot.org/citations/18234856 | http://www.w3.org/2000/01/rdf-schema#comment | "We describe a method for rapid identification of protein kinase substrates. Cdk1 was engineered to accept an ATP analog that allows it to uniquely label its substrates with a bio-orthogonal phosphate analog tag. A highly specific, covalent capture-and-release methodology was developed for rapid purification of tagged peptides derived from labeled substrate proteins. Application of this approach to the discovery of Cdk1-cyclin B substrates yielded identification of >70 substrates and phosphorylation sites. Many of these sites are known to be phosphorylated in vivo, but most of the proteins have not been characterized as Cdk1-cyclin B substrates. This approach has the potential to expand our understanding of kinase-substrate connections in signaling networks."xsd:string |
http://purl.uniprot.org/citations/18234856 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0708966105"xsd:string |
http://purl.uniprot.org/citations/18234856 | http://purl.uniprot.org/core/author | "Shokat K.M."xsd:string |
http://purl.uniprot.org/citations/18234856 | http://purl.uniprot.org/core/author | "Morgan D.O."xsd:string |
http://purl.uniprot.org/citations/18234856 | http://purl.uniprot.org/core/author | "Blethrow J.D."xsd:string |
http://purl.uniprot.org/citations/18234856 | http://purl.uniprot.org/core/author | "Glavy J.S."xsd:string |
http://purl.uniprot.org/citations/18234856 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
http://purl.uniprot.org/citations/18234856 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
http://purl.uniprot.org/citations/18234856 | http://purl.uniprot.org/core/pages | "1442-1447"xsd:string |
http://purl.uniprot.org/citations/18234856 | http://purl.uniprot.org/core/title | "Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates."xsd:string |
http://purl.uniprot.org/citations/18234856 | http://purl.uniprot.org/core/volume | "105"xsd:string |
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