| http://purl.uniprot.org/citations/18235504 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18235504 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18235504 | http://www.w3.org/2000/01/rdf-schema#comment | "The M2 protein from influenza A virus is a pH-activated proton channel that mediates acidification of the interior of viral particles entrapped in endosomes. M2 is the target of the anti-influenza drugs amantadine and rimantadine; recently, resistance to these drugs in humans, birds and pigs has reached more than 90% (ref. 1). Here we describe the crystal structure of the transmembrane-spanning region of the homotetrameric protein in the presence and absence of the channel-blocking drug amantadine. pH-dependent structural changes occur near a set of conserved His and Trp residues that are involved in proton gating. The drug-binding site is lined by residues that are mutated in amantadine-resistant viruses. Binding of amantadine physically occludes the pore, and might also perturb the pK(a) of the critical His residue. The structure provides a starting point for solving the problem of resistance to M2-channel blockers."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature06528"xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature06528"xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "Levine A.S."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "Levine A.S."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "Di Costanzo L."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "Di Costanzo L."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "Salom D."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "Salom D."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "Nanda V."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "Nanda V."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "Acharya R."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "Acharya R."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "Tereshko V."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "Tereshko V."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "DeGrado W.F."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "DeGrado W.F."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "Stayrook S."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "Stayrook S."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "Soto C.S."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "Soto C.S."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "Stouffer A.L."xsd:string |
| http://purl.uniprot.org/citations/18235504 | http://purl.uniprot.org/core/author | "Stouffer A.L."xsd:string |