| http://purl.uniprot.org/citations/18238900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18238900 | http://www.w3.org/2000/01/rdf-schema#comment | "Administration of beta-sitosterol (42 mg/kg per day) for 3 weeks to 8-month-old male LXRbeta-/-mice resulted in the death of motor neurons in the lumbar region of the spinal cord and loss of tyrosine hydroxylase-positive dopaminergic neurons in the substantia nigra. In mice at 5 months of age, beta-sitosterol had no observed toxicity but at 16 months of age, it caused severe paralysis and symptoms typical of dopaminergic dysfunction in LXRbeta-/-mice. WT mice were not affected by these doses of beta-sitosterol. In 5-month-old mice, levels of the intestinal transporters, ABCG5/8 and Niemann-Pick C1 Like 1, were not affected by loss of liver X receptor (LXR) beta and/or treatment with beta-sitosterol nor were there changes in plasma levels of cholesterol or beta-sitosterol. In 8-month-old LXRbeta-/-mice there was activation of microglia in the substantia nigra pars reticulata and aggregates of ubiquitin and TDP-43 in the cytoplasm of large motor neurons in the lumbar spinal cord. Brain cholesterol concentrations were higher in LXRbeta-/-than in their WT counterparts, and treatment with beta-sitosterol reduced brain cholesterol in both WT and LXRbeta-/- mice. In LXRbeta-/-mice but not in WT mice levels of 24-hydrocholesterol were increased upon beta-sitosterol treatment. These data indicate that multiple mechanisms are involved in the sensitivity of LXRbeta-/-mice to beta-sitosterol. These include activation of microglia, accumulation of protein aggregates in the cytoplasm of large motor neurons, and depletion of brain cholesterol."xsd:string |
| http://purl.uniprot.org/citations/18238900 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0711599105"xsd:string |
| http://purl.uniprot.org/citations/18238900 | http://purl.uniprot.org/core/author | "Fan X."xsd:string |
| http://purl.uniprot.org/citations/18238900 | http://purl.uniprot.org/core/author | "Kim H.J."xsd:string |
| http://purl.uniprot.org/citations/18238900 | http://purl.uniprot.org/core/author | "Gustafsson J.A."xsd:string |
| http://purl.uniprot.org/citations/18238900 | http://purl.uniprot.org/core/author | "Warner M."xsd:string |
| http://purl.uniprot.org/citations/18238900 | http://purl.uniprot.org/core/author | "Gabbi C."xsd:string |
| http://purl.uniprot.org/citations/18238900 | http://purl.uniprot.org/core/author | "Parini P."xsd:string |
| http://purl.uniprot.org/citations/18238900 | http://purl.uniprot.org/core/author | "Yakimchuk K."xsd:string |
| http://purl.uniprot.org/citations/18238900 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18238900 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/18238900 | http://purl.uniprot.org/core/pages | "2094-2099"xsd:string |
| http://purl.uniprot.org/citations/18238900 | http://purl.uniprot.org/core/title | "Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia."xsd:string |
| http://purl.uniprot.org/citations/18238900 | http://purl.uniprot.org/core/volume | "105"xsd:string |
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