| http://purl.uniprot.org/citations/18239084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18239084 | http://www.w3.org/2000/01/rdf-schema#comment | "Erythropoiesis requires erythropoietin (Epo) and stem cell factor (SCF) signaling via their receptors EpoR and c-Kit. EpoR, like many other receptors involved in hematopoiesis, acts via the kinase Jak2. Deletion of EpoR or Janus kinase 2 (Jak2) causes embryonic lethality as a result of defective erythropoiesis. The contribution of distinct EpoR/Jak2-induced signaling pathways (mitogen-activated protein kinase, phosphatidylinositol 3-kinase, signal transducer and activator of transcription 5 [Stat5]) to functional erythropoiesis is incompletely understood. Here we demonstrate that expression of a constitutively activated Stat5a mutant (cS5) was sufficient to relieve the proliferation defect of Jak2(-/-) and EpoR(-/-) cells in an Epo-independent manner. In addition, tamoxifen-induced DNA binding of a Stat5a-estrogen receptor (ER)* fusion construct enabled erythropoiesis in the absence of Epo. Furthermore, c-Kit was able to enhance signaling through the Jak2-Stat5 axis, particularly in lymphoid and myeloid progenitors. Although abundance of hematopoietic stem cells was 2.5-fold reduced in Jak2(-/-) fetal livers, transplantation of Jak2(-/-)-cS5 fetal liver cells into irradiated mice gave rise to mature erythroid and myeloid cells of donor origin up to 6 months after transplantation. Cytokine- and c-Kit pathways do not function independently of each other in hematopoiesis but cooperate to attain full Jak2/Stat5 activation. In conclusion, activated Stat5 is a critical downstream effector of Jak2 in erythropoiesis/myelopoiesis, and Jak2 functionally links cytokine-with c-Kit-receptor tyrosine kinase signaling."xsd:string |
| http://purl.uniprot.org/citations/18239084 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2007-07-102848"xsd:string |
| http://purl.uniprot.org/citations/18239084 | http://purl.uniprot.org/core/author | "Muller M."xsd:string |
| http://purl.uniprot.org/citations/18239084 | http://purl.uniprot.org/core/author | "Beug H."xsd:string |
| http://purl.uniprot.org/citations/18239084 | http://purl.uniprot.org/core/author | "Grebien F."xsd:string |
| http://purl.uniprot.org/citations/18239084 | http://purl.uniprot.org/core/author | "Moriggl R."xsd:string |
| http://purl.uniprot.org/citations/18239084 | http://purl.uniprot.org/core/author | "Pfeffer K."xsd:string |
| http://purl.uniprot.org/citations/18239084 | http://purl.uniprot.org/core/author | "Dolznig H."xsd:string |
| http://purl.uniprot.org/citations/18239084 | http://purl.uniprot.org/core/author | "Klingmuller U."xsd:string |
| http://purl.uniprot.org/citations/18239084 | http://purl.uniprot.org/core/author | "Kolbe T."xsd:string |
| http://purl.uniprot.org/citations/18239084 | http://purl.uniprot.org/core/author | "Becker V."xsd:string |
| http://purl.uniprot.org/citations/18239084 | http://purl.uniprot.org/core/author | "Mullner E.W."xsd:string |
| http://purl.uniprot.org/citations/18239084 | http://purl.uniprot.org/core/author | "Kovacic B."xsd:string |
| http://purl.uniprot.org/citations/18239084 | http://purl.uniprot.org/core/author | "Kerenyi M.A."xsd:string |
| http://purl.uniprot.org/citations/18239084 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18239084 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/18239084 | http://purl.uniprot.org/core/pages | "4511-4522"xsd:string |
| http://purl.uniprot.org/citations/18239084 | http://purl.uniprot.org/core/title | "Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2."xsd:string |
| http://purl.uniprot.org/citations/18239084 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/18239084 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18239084 |
| http://purl.uniprot.org/citations/18239084 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18239084 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SRC0-mappedCitation-18239084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18239084 |
| http://purl.uniprot.org/uniprot/#_A2A5D3-mappedCitation-18239084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18239084 |
| http://purl.uniprot.org/uniprot/#_A2A5D4-mappedCitation-18239084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18239084 |