| http://purl.uniprot.org/citations/18239087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18239087 | http://www.w3.org/2000/01/rdf-schema#comment | "Inside-out signaling regulation of the beta2-integrin leukocyte function-associated antigen-1 (LFA-1) by different cytoplasmic proteins, including 14-3-3 proteins, is essential for adhesion and migration of immune cells. Here, we identify a new pathway for the regulation of LFA-1 activity by Cbl-b, an adapter molecule and ubiquitin ligase that modulates several signaling pathways. Cbl-b-/-mice displayed increased macrophage recruitment in thioglycollate-induced peritonitis, which was attributed to Cbl-b deficiency in macrophages, as assessed by bone marrow chimera experiments. In vitro, Cbl-b-/-bone marrow-derived mononuclear phagocytes (BMDMs) displayed increased adhesion to endothelial cells. Activation of LFA-1 in Cbl-b-deficient cells was responsible for their increased endothelial adhesion in vitro and peritoneal recruitment in vivo, as the phenotype of Cbl-b deficiency was reversed in Cbl-b-/-LFA-1-/-mice. Consistently, LFA-1-mediated adhesion of BMDM to ICAM-1 but not VLA-4-mediated adhesion to VCAM-1 was enhanced by Cbl-b deficiency. Cbl-b deficiency resulted in increased phosphorylation of T758 in the beta2-chain of LFA-1 and thereby in enhanced association of 14-3-3beta protein with the beta2-chain, leading to activation of LFA-1. Consistently, disruption of the 14-3-3/beta2-integrin interaction abrogated the enhanced ICAM-1 adhesion of Cbl-b-/-BMDMs. In conclusion, Cbl-b deficiency activates LFA-1 and LFA-1-mediated inflammatory cell recruitment by stimulating the interaction between the LFA-1 beta-chain and 14-3-3 proteins."xsd:string |
| http://purl.uniprot.org/citations/18239087 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2007-07-103077"xsd:string |
| http://purl.uniprot.org/citations/18239087 | http://purl.uniprot.org/core/author | "Fagerholm S.C."xsd:string |
| http://purl.uniprot.org/citations/18239087 | http://purl.uniprot.org/core/author | "Gahmberg C.G."xsd:string |
| http://purl.uniprot.org/citations/18239087 | http://purl.uniprot.org/core/author | "Nurmi S.M."xsd:string |
| http://purl.uniprot.org/citations/18239087 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/18239087 | http://purl.uniprot.org/core/author | "Chavakis T."xsd:string |
| http://purl.uniprot.org/citations/18239087 | http://purl.uniprot.org/core/author | "Orlova V.V."xsd:string |
| http://purl.uniprot.org/citations/18239087 | http://purl.uniprot.org/core/author | "Choi E.Y."xsd:string |
| http://purl.uniprot.org/citations/18239087 | http://purl.uniprot.org/core/author | "Ballantyne C.M."xsd:string |
| http://purl.uniprot.org/citations/18239087 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18239087 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/18239087 | http://purl.uniprot.org/core/pages | "3607-3614"xsd:string |
| http://purl.uniprot.org/citations/18239087 | http://purl.uniprot.org/core/title | "Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins."xsd:string |
| http://purl.uniprot.org/citations/18239087 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/18239087 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18239087 |
| http://purl.uniprot.org/citations/18239087 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18239087 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP17-mappedCitation-18239087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18239087 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP47-mappedCitation-18239087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18239087 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP95-mappedCitation-18239087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18239087 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNF1-mappedCitation-18239087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18239087 |
| http://purl.uniprot.org/uniprot/#_D3YW95-mappedCitation-18239087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18239087 |
| http://purl.uniprot.org/uniprot/#_D3YYP8-mappedCitation-18239087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18239087 |
| http://purl.uniprot.org/uniprot/#_D3Z1S4-mappedCitation-18239087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18239087 |