| http://purl.uniprot.org/citations/18239465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18239465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18239465 | http://www.w3.org/2000/01/rdf-schema#comment | "Aurora-B and -C kinases are members of the Aurora serine/threonine kinase family of mitotic regulators. Aurora-B kinase is evolutionarily conserved from yeast to humans and has multiple functions in chromosome condensation, cohesion, biorientation and in cytokinesis. In contrast, Aurora-C kinase has only been found in mammals, is upregulated in some tumor cell lines and tissues, and has a unique physiological role in spermiogenesis. Despite these known functions, little is known about the function of Aurora-C in mitosis. We have found that Aurora-C interacts with Borealin in addition to the other known members of the Aurora-B chromosomal passenger complex (CPC). We have also found that Aurora-C, like Aurora-B, phosphorylates the centromeric histone Centromere Protein-A (CENP-A) and Borealin in vitro. These molecular mechanisms are consistent with our observation that in the absence of Aurora-B, Aurora-C is sufficient for proper mitotic phosphorylation of CENP-A and centromeric localization of the CPC proteins. Thus, Aurora-C shares Aurora-B substrates and is capable of performing mitotic functions previously attributed only to Aurora-B."xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://purl.org/dc/terms/identifier | "doi:10.4161/cc.7.6.5563"xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://purl.org/dc/terms/identifier | "doi:10.4161/cc.7.6.5563"xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://purl.uniprot.org/core/author | "Hall R.M."xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://purl.uniprot.org/core/author | "Hall R.M."xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://purl.uniprot.org/core/author | "Brinkley B.R."xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://purl.uniprot.org/core/author | "Brinkley B.R."xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://purl.uniprot.org/core/author | "Moore R.V."xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://purl.uniprot.org/core/author | "Moore R.V."xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://purl.uniprot.org/core/author | "Slattery S.D."xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://purl.uniprot.org/core/author | "Slattery S.D."xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18239465 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18239465 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://purl.uniprot.org/core/pages | "787-795"xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://purl.uniprot.org/core/pages | "787-795"xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://purl.uniprot.org/core/title | "Aurora-C and Aurora-B share phosphorylation and regulation of CENP-A and Borealin during mitosis."xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://purl.uniprot.org/core/title | "Aurora-C and Aurora-B share phosphorylation and regulation of CENP-A and Borealin during mitosis."xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/18239465 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18239465 |
| http://purl.uniprot.org/citations/18239465 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18239465 |