| http://purl.uniprot.org/citations/18240960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18240960 | http://www.w3.org/2000/01/rdf-schema#comment | "Nucleoside analog-associated sensory neuropathy (NRTI-SN) attributed to stavudine, didanosine, or zalcitabine (the dNRTIs) and distal sensory polyneuropathy (DSP) attributed to HIV are clinically indistinguishable. As inflammatory cytokines are involved in DSP, we addressed a role for inflammation in NRTI-SN by determining the alleles of immune-related genes carried by patients with and without NRTI-SN. Demographic details associated with risk of various neuropathies were included in the analysis. Alleles of 14 polymorphisms in 10 genes were determined in Australian HIV patients with definite NRTI-SN (symptom onset <6 months after first dNRTI exposure, n = 16), NRTI-SN-resistant patients (no neuropathy despite >6 months on dNRTIs, n = 20), patients with late onset NRTI-SN (neuropathy onset after >6 months of dNRTIs, n = 19), and HIV-negative controls. Carriage of TNFA-1031*2 was highest in NRTI-SN patients, suggesting potentiation of NRTI-SN. Carriage of IL12B (3' UTR)*2 was higher in NRTI-SN-resistant patients than controls or NRTI-SN patients, suggesting a protective role. BAT1 (intron 10)*2 was more common in NRTI-SN than resistant patients, but neither group differed from controls. This marks the conserved HLA-A1, B8, DR3 haplotype. Of the demographic details considered, increasing height was associated with NRTI-SN risk. A model including cytokine genotype and height predicted NRTI-SN status (p < 0.0001, R(2) = 0.54). Late onset NRTI-SN patients clustered genetically with NRTI-SN-resistant patients, so these patients may be genetically "protected." In addition to patient height, cytokine genotype influenced NRTI-SN risk following dNRTI exposure, suggesting inflammation contributes to NRTI-SN."xsd:string |
| http://purl.uniprot.org/citations/18240960 | http://purl.org/dc/terms/identifier | "doi:10.1089/aid.2007.0168"xsd:string |
| http://purl.uniprot.org/citations/18240960 | http://purl.uniprot.org/core/author | "Rosenow A."xsd:string |
| http://purl.uniprot.org/citations/18240960 | http://purl.uniprot.org/core/author | "McArthur J.C."xsd:string |
| http://purl.uniprot.org/citations/18240960 | http://purl.uniprot.org/core/author | "Wesselingh S.L."xsd:string |
| http://purl.uniprot.org/citations/18240960 | http://purl.uniprot.org/core/author | "Price P."xsd:string |
| http://purl.uniprot.org/citations/18240960 | http://purl.uniprot.org/core/author | "Affandi J.S."xsd:string |
| http://purl.uniprot.org/citations/18240960 | http://purl.uniprot.org/core/author | "Cherry C.L."xsd:string |
| http://purl.uniprot.org/citations/18240960 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18240960 | http://purl.uniprot.org/core/name | "AIDS Res Hum Retroviruses"xsd:string |
| http://purl.uniprot.org/citations/18240960 | http://purl.uniprot.org/core/pages | "117-123"xsd:string |
| http://purl.uniprot.org/citations/18240960 | http://purl.uniprot.org/core/title | "Cytokine genotype suggests a role for inflammation in nucleoside analog-associated sensory neuropathy (NRTI-SN) and predicts an individual's NRTI-SN risk."xsd:string |
| http://purl.uniprot.org/citations/18240960 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/18240960 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18240960 |
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| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-18240960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18240960 |