| http://purl.uniprot.org/citations/18241227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18241227 | http://www.w3.org/2000/01/rdf-schema#comment | "The aetiology of idiopathic bronchiectasis, a lung disease where chronic inflammation and bacterial infection leads to progressive lung damage, is unknown. A possible role for natural killer cells has been highlighted previously. However, a role for adaptive immunity is suggested by the presence of CD4 and CD8 T cells in diseased lung tissue. Evidence of a human leucocyte antigen (HLA) class II disease association would further implicate a role for adaptive immunity. To establish if there is any HLA association, we analysed HLA-A, HLA-B, HLA-DQA1, HLA-DQB1 and HLA-DRB1 alleles in patients with idiopathic bronchiectasis and controls. Genomic DNA from 92 adults with idiopathic bronchiectasis and 101 healthy controls was analysed by polymerase chain reaction with sequence-specific primers. We found an increase in the prevalence of HLA-DRB1*01 DQA1*01/DQB1*05 genes in idiopathic bronchiectasis; that is, the HLA-DR1, DQ5 haplotype (odds ratio 2.19, 95% confidence interval 1.15-4.16, P = 0.0152) compared with control subjects. The association with HLA-DR1, DQ5 implicates a role for CD4 T cells restricted by these molecules in susceptibility to the progressive lung damage seen in this disease. This may operate either through influencing susceptibility to specific pathogens or to self-reactivity and requires further investigation."xsd:string |
| http://purl.uniprot.org/citations/18241227 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2249.2008.03596.x"xsd:string |
| http://purl.uniprot.org/citations/18241227 | http://purl.uniprot.org/core/author | "Jones M."xsd:string |
| http://purl.uniprot.org/citations/18241227 | http://purl.uniprot.org/core/author | "Rose M."xsd:string |
| http://purl.uniprot.org/citations/18241227 | http://purl.uniprot.org/core/author | "Smith J."xsd:string |
| http://purl.uniprot.org/citations/18241227 | http://purl.uniprot.org/core/author | "Wilson R."xsd:string |
| http://purl.uniprot.org/citations/18241227 | http://purl.uniprot.org/core/author | "Chaudhry A."xsd:string |
| http://purl.uniprot.org/citations/18241227 | http://purl.uniprot.org/core/author | "Reynolds C."xsd:string |
| http://purl.uniprot.org/citations/18241227 | http://purl.uniprot.org/core/author | "Altmann D.M."xsd:string |
| http://purl.uniprot.org/citations/18241227 | http://purl.uniprot.org/core/author | "Boyton R.J."xsd:string |
| http://purl.uniprot.org/citations/18241227 | http://purl.uniprot.org/core/author | "Ozerovitch L."xsd:string |
| http://purl.uniprot.org/citations/18241227 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18241227 | http://purl.uniprot.org/core/name | "Clin Exp Immunol"xsd:string |
| http://purl.uniprot.org/citations/18241227 | http://purl.uniprot.org/core/pages | "95-101"xsd:string |
| http://purl.uniprot.org/citations/18241227 | http://purl.uniprot.org/core/title | "Human leucocyte antigen class II association in idiopathic bronchiectasis, a disease of chronic lung infection, implicates a role for adaptive immunity."xsd:string |
| http://purl.uniprot.org/citations/18241227 | http://purl.uniprot.org/core/volume | "152"xsd:string |
| http://purl.uniprot.org/citations/18241227 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18241227 |
| http://purl.uniprot.org/citations/18241227 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18241227 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-18241227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18241227 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-18241227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18241227 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-18241227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18241227 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-18241227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18241227 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-18241227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18241227 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-18241227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18241227 |