| http://purl.uniprot.org/citations/18241854 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18241854 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulin regulates development, metabolism, and lifespan via a conserved PI3K/Akt pathway that promotes cytoplasmic sequestration of FoxO transcription factors. The regulation of nuclear FoxO is poorly understood. In the nematode Caenorhabditis elegans, insulin-like signaling functions in larvae to inhibit dauer arrest and acts during adulthood to regulate lifespan. In a screen for genes that modulate C. elegans insulin-like signaling, we identified eak-3, which encodes a novel protein that is specifically expressed in the two endocrine XXX cells. The dauer arrest phenotype of eak-3 mutants is fully suppressed by mutations in daf-16/FoxO, which encodes the major target of C. elegans insulin-like signaling, and daf-12, which encodes a nuclear receptor regulated by steroid hormones known as dafachronic acids. eak-3 mutation does not affect DAF-16/FoxO subcellular localization but enhances expression of the direct DAF-16/FoxO target sod-3 in a daf-16/FoxO- and daf-12-dependent manner. eak-3 mutants have normal lifespans, suggesting that EAK-3 decouples insulin-like regulation of development and longevity. We propose that EAK-3 activity in the XXX cells promotes the synthesis and/or secretion of a hormone that acts in parallel to AKT-1 to inhibit the expression of DAF-16/FoxO target genes. Similar hormonal pathways may regulate FoxO target gene expression in mammals."xsd:string |
| http://purl.uniprot.org/citations/18241854 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2007.12.032"xsd:string |
| http://purl.uniprot.org/citations/18241854 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/18241854 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/18241854 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/18241854 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/18241854 | http://purl.uniprot.org/core/author | "Hu P.J."xsd:string |
| http://purl.uniprot.org/citations/18241854 | http://purl.uniprot.org/core/author | "Alam H."xsd:string |
| http://purl.uniprot.org/citations/18241854 | http://purl.uniprot.org/core/author | "Puscau C."xsd:string |
| http://purl.uniprot.org/citations/18241854 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18241854 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/18241854 | http://purl.uniprot.org/core/pages | "290-302"xsd:string |
| http://purl.uniprot.org/citations/18241854 | http://purl.uniprot.org/core/title | "Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity."xsd:string |
| http://purl.uniprot.org/citations/18241854 | http://purl.uniprot.org/core/volume | "315"xsd:string |
| http://purl.uniprot.org/citations/18241854 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18241854 |
| http://purl.uniprot.org/citations/18241854 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18241854 |
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| http://purl.uniprot.org/uniprot/#_A0A0K3AUA1-mappedCitation-18241854 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18241854 |