| http://purl.uniprot.org/citations/18242151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18242151 | http://www.w3.org/2000/01/rdf-schema#comment | "Aberrant oxidation is a property of many tumor cells. Oxidation of DNA precursors, i.e., deoxynucleotide triphosphates (dNTPs), as well as DNA is a major cause of genome instability. Here, we report that human DNA polymerase eta (h Poleta) incorporates oxidized dNTPs, i.e., 2-hydroxy-2'-deoxyadenosine 5'-triphosphate (2-OH-dATP) and 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (8-OH-dGTP), into DNA in an erroneous and efficient manner, thereby inducing various types of mutations during in vitro gap-filling DNA synthesis. When 2-OH-dATP was present at a concentration equal to those of the four normal dNTPs in the reaction mixture, DNA synthesis by h Poleta enhanced the frequency of G-to-T transversions eight-fold higher than that of the transversions in control where only the normal dNTPs were present. When 8-OH-dGTP was present at an equimolar concentration to the normal dNTPs, it enhanced the frequency of A-to-C transversions 17-fold higher than the control. It also increased the frequency of C-to-A transversions about two-fold. These results suggest that h Poleta incorporates 2-OH-dATP opposite template G and incorporates 8-OH-dGTP opposite template A and slightly opposite template C during DNA synthesis. Besides base substitutions, h Poleta enhanced the frequency of single-base frameshifts and deletions with the size of more than 100 base pairs when 8-OH-dGTP was present in the reaction mixture. Since h Poleta is present in replication foci even without exogenous DNA damage, we suggest that h Poleta may be involved in induction of various types of mutations through the erroneous and efficient incorporation of oxidized dNTPs into DNA in human cells."xsd:string |
| http://purl.uniprot.org/citations/18242151 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.dnarep.2007.12.005"xsd:string |
| http://purl.uniprot.org/citations/18242151 | http://purl.uniprot.org/core/author | "Hanaoka F."xsd:string |
| http://purl.uniprot.org/citations/18242151 | http://purl.uniprot.org/core/author | "Yamada M."xsd:string |
| http://purl.uniprot.org/citations/18242151 | http://purl.uniprot.org/core/author | "Kamiya H."xsd:string |
| http://purl.uniprot.org/citations/18242151 | http://purl.uniprot.org/core/author | "Nohmi T."xsd:string |
| http://purl.uniprot.org/citations/18242151 | http://purl.uniprot.org/core/author | "Harashima H."xsd:string |
| http://purl.uniprot.org/citations/18242151 | http://purl.uniprot.org/core/author | "Hidaka K."xsd:string |
| http://purl.uniprot.org/citations/18242151 | http://purl.uniprot.org/core/author | "Masutani C."xsd:string |
| http://purl.uniprot.org/citations/18242151 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18242151 | http://purl.uniprot.org/core/name | "DNA Repair (Amst)"xsd:string |
| http://purl.uniprot.org/citations/18242151 | http://purl.uniprot.org/core/pages | "497-506"xsd:string |
| http://purl.uniprot.org/citations/18242151 | http://purl.uniprot.org/core/title | "Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase eta."xsd:string |
| http://purl.uniprot.org/citations/18242151 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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