| http://purl.uniprot.org/citations/18242781 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18242781 | http://www.w3.org/2000/01/rdf-schema#comment | "Human postmortem studies have reported decreases with age in high affinity nicotine binding in brain. We investigated the effect of age on beta(2)-containing nicotinic acetylcholine receptor (beta(2)-nAChR) availability in eight brain regions of living human subjects using the ligand [(123)I]5-IA-85380 ([(123)I]5-IA) and single photon emission computed tomography (SPECT). Healthy, nonsmokers (N=47) ranging in age from 18 to 85 were administered [(123)I]5-IA using a bolus plus constant infusion paradigm and imaged 6-8h later under equilibrium conditions. The effect of age on regional beta(2)-nAChR availability (V(T), regional brain activity/free plasma parent, a measure proportional to the binding potential) was analyzed using linear regression and Pearson's correlation (r). Age and regional beta(2)-nAChR availability were inversely correlated in seven of the eight brain regions analyzed, with decline ranging from 32% (thalamus) to 18% (occipital cortex) over the adult lifespan, or up to 5% per decade. These results in living human subjects corroborate postmortem reports of decline in high affinity nicotine binding with age and may aid in elucidating the role of beta(2)-nAChRs in cognitive aging."xsd:string |
| http://purl.uniprot.org/citations/18242781 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neurobiolaging.2007.12.008"xsd:string |
| http://purl.uniprot.org/citations/18242781 | http://purl.uniprot.org/core/author | "Bois F."xsd:string |
| http://purl.uniprot.org/citations/18242781 | http://purl.uniprot.org/core/author | "Staley J.K."xsd:string |
| http://purl.uniprot.org/citations/18242781 | http://purl.uniprot.org/core/author | "Seibyl J.P."xsd:string |
| http://purl.uniprot.org/citations/18242781 | http://purl.uniprot.org/core/author | "van Dyck C.H."xsd:string |
| http://purl.uniprot.org/citations/18242781 | http://purl.uniprot.org/core/author | "Cosgrove K.P."xsd:string |
| http://purl.uniprot.org/citations/18242781 | http://purl.uniprot.org/core/author | "Tamagnan G.D."xsd:string |
| http://purl.uniprot.org/citations/18242781 | http://purl.uniprot.org/core/author | "Estok K.M."xsd:string |
| http://purl.uniprot.org/citations/18242781 | http://purl.uniprot.org/core/author | "Frohlich E.B."xsd:string |
| http://purl.uniprot.org/citations/18242781 | http://purl.uniprot.org/core/author | "Mitsis E.M."xsd:string |
| http://purl.uniprot.org/citations/18242781 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18242781 | http://purl.uniprot.org/core/name | "Neurobiol Aging"xsd:string |
| http://purl.uniprot.org/citations/18242781 | http://purl.uniprot.org/core/pages | "1490-1497"xsd:string |
| http://purl.uniprot.org/citations/18242781 | http://purl.uniprot.org/core/title | "Age-related decline in nicotinic receptor availability with [(123)I]5-IA-85380 SPECT."xsd:string |
| http://purl.uniprot.org/citations/18242781 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/18242781 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18242781 |
| http://purl.uniprot.org/citations/18242781 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18242781 |
| http://purl.uniprot.org/uniprot/#_P17787-mappedCitation-18242781 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18242781 |
| http://purl.uniprot.org/uniprot/#_Q5SXY3-mappedCitation-18242781 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18242781 |
| http://purl.uniprot.org/uniprot/P17787 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18242781 |
| http://purl.uniprot.org/uniprot/Q5SXY3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18242781 |