| http://purl.uniprot.org/citations/18245856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18245856 | http://www.w3.org/2000/01/rdf-schema#comment | "How spatial, temporal, and sexual specific cues are integrated to specify distinct cell fates during multicellular organism development is largely unknown. Here we demonstrate that the Caenorhabditis elegans PcG-like gene sop-2 determines the temporal and sexual specificities of a row of hypodermal seam cells, in addition to specifying their positional identities. Loss-of-function of sop-2 causes premature expression of adult fates at larval stages. sop-2 acts upstream of lin-29 in the heterochronic pathway and genetically interacts with other heterochronic genes in specifying the temporal fates of seam cells at different larval stages. We show that the number of ALG-1-containing P bodies is increased in seam cells in sop-2 mutants. Furthermore, the microRNA-mediated repression of a heterochronic gene reporter is enhanced in sop-2 mutants. Mutations in sop-2 also cause partial hermaphrodite-to-male sexual transformations. The homeotic transformations, heterochronic defects, and sexual transformations can occur concomitantly in sop-2 mutants. In summary, our studies reveal that sop-2 integrates spatial, temporal, and sexual cues during C. elegans development."xsd:string |
| http://purl.uniprot.org/citations/18245856 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.108.086678"xsd:string |
| http://purl.uniprot.org/citations/18245856 | http://purl.uniprot.org/core/author | "Cai Q."xsd:string |
| http://purl.uniprot.org/citations/18245856 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/18245856 | http://purl.uniprot.org/core/author | "Guo C."xsd:string |
| http://purl.uniprot.org/citations/18245856 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/18245856 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/18245856 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/18245856 | http://purl.uniprot.org/core/author | "Zhu Z."xsd:string |
| http://purl.uniprot.org/citations/18245856 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18245856 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/18245856 | http://purl.uniprot.org/core/pages | "1445-1456"xsd:string |
| http://purl.uniprot.org/citations/18245856 | http://purl.uniprot.org/core/title | "The Caenorhabditis elegans PcG-like gene sop-2 regulates the temporal and sexual specificities of cell fates."xsd:string |
| http://purl.uniprot.org/citations/18245856 | http://purl.uniprot.org/core/volume | "178"xsd:string |
| http://purl.uniprot.org/citations/18245856 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18245856 |
| http://purl.uniprot.org/citations/18245856 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18245856 |
| http://purl.uniprot.org/uniprot/Q965H3#attribution-E66C68637D965D1C99AB14102E1E2488 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18245856 |
| http://purl.uniprot.org/uniprot/H8P172#attribution-E66C68637D965D1C99AB14102E1E2488 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18245856 |
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| http://purl.uniprot.org/uniprot/#_H8P173-mappedCitation-18245856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18245856 |
| http://purl.uniprot.org/uniprot/#_G5EES3-mappedCitation-18245856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18245856 |
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| http://purl.uniprot.org/uniprot/#_Q86B39-mappedCitation-18245856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18245856 |