| http://purl.uniprot.org/citations/18246054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18246054 | http://www.w3.org/2000/01/rdf-schema#comment | "Inflammatory bowel disease (IBD) is a complex genetic disorder of two major phenotypes, Crohn's disease (CD) and ulcerative colitis (UC), with increased risk in Ashkenazi Jews. Twelve genome-wide linkage screens have identified multiple loci, but these screens have been of modest size and have used low-density microsatellite markers. We, therefore, performed a high-density single-nucleotide polymorphism (SNP) genome-wide linkage study of 993 IBD multiply affected pedigrees (25% Jewish ancestry) that contained 1709 IBD-affected relative pairs, including 919 CD-CD pairs and 312 UC-UC pairs. We identified a significant novel CD locus on chromosome 13p13.3 (peak logarithm of the odds (LOD) score=3.98) in all pedigrees, significant linkage evidence on chromosomes 1p35.1 (peak LOD score=3.5) and 3q29 (peak LOD score=3.19) in Jewish CD pedigrees, and suggestive loci for Jewish IBD on chromosome 10q22 (peak LOD score=2.57) and Jewish UC on chromosome 2q24 (peak LOD score=2.69). Nominal or greater linkage evidence was present for most previously designated IBD loci (IBD1-9), notably, IBD1 for CD families at chromosome 16q12.1 (peak LOD score=4.86) and IBD6 in non-Jewish UC families at chromosome 19p12 (peak LOD score=2.67). This study demonstrates the ability of high information content adequately powered SNP genome-wide linkage studies to identify loci not observed in multiple microsatellite-based studies in smaller cohorts."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.gene.6364460"xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Barmada M.M."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Brant S.R."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Cho J.H."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Duerr R.H."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Griffiths A.M."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Mei L."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Rioux J.D."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Rotter J.I."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Schumm L.P."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Shugart Y.Y."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Silverberg M.S."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Steinhart A.H."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Taylor K.D."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Cohen A."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Wang M.H."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Bernstein C.N."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Bitton A."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Bayless T.M."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Langelier D."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Kane S.V."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Bromfield G."xsd:string |
| http://purl.uniprot.org/citations/18246054 | http://purl.uniprot.org/core/author | "Zarfas K."xsd:string |