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http://purl.uniprot.org/citations/18247309http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18247309http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To study the relationship between CYP1A1 genetic polymorphism and intrahepatic cholestasis of pregnancy (ICP) in Chengdu of China.

Methods

MspI and Ile/Val genotypes of CYP1A1 gene were detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and allele-specific amplification-PCR (ASA-PCR) in a case-control study, including 100 cases of ICP and 100 controls.

Results

There was no significant correlation between MspI polymorphism and ICP susceptibility (P>0.05). However, the Ile/Val+Val/Val genotypes of CYP1A1 significantly increased the risk of ICP (P=0.047, OR=1.768).

Conclusion

The Ile/Val polymorphism in exon 7 of CYP1A1 may be associated with the susceptibility of ICP in Chengdu. The MspI polymorphism of CYP1A1 is not associated with the risk of ICP in Chengdu."xsd:string
http://purl.uniprot.org/citations/18247309http://purl.uniprot.org/core/author"Chen Q."xsd:string
http://purl.uniprot.org/citations/18247309http://purl.uniprot.org/core/author"Wang J."xsd:string
http://purl.uniprot.org/citations/18247309http://purl.uniprot.org/core/author"Wang X."xsd:string
http://purl.uniprot.org/citations/18247309http://purl.uniprot.org/core/author"Zhang L."xsd:string
http://purl.uniprot.org/citations/18247309http://purl.uniprot.org/core/author"Liu S.Y."xsd:string
http://purl.uniprot.org/citations/18247309http://purl.uniprot.org/core/author"Su P.C."xsd:string
http://purl.uniprot.org/citations/18247309http://purl.uniprot.org/core/author"Ou R.Q."xsd:string
http://purl.uniprot.org/citations/18247309http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18247309http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/18247309http://purl.uniprot.org/core/pages"70-72"xsd:string
http://purl.uniprot.org/citations/18247309http://purl.uniprot.org/core/title"[Association between CYP1A1 gene polymorphism and intrahepatic cholestasis of pregnancy]."xsd:string
http://purl.uniprot.org/citations/18247309http://purl.uniprot.org/core/volume"25"xsd:string
http://purl.uniprot.org/citations/18247309http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18247309
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