| http://purl.uniprot.org/citations/18248305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18248305 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundCryptosporidium species are a common cause of diarrhea, which can be severe and protracted in young children and immunocompromised individuals.MethodsA cohort of 226 Bangladeshi children aged 2-5 years was prospectively followed for >3 years to study the role of host genetics in susceptibility to infection, as well as the community impact of cryptosporidiosis on this population.ResultsNinety-six children (42.5%) received a diagnosis of Cryptosporidium infection. A total of 51 (22.6%) had asymptomatic infection. Fifty-eight (25.7%) had cryptosporidiosis, of whom 17 (29.3%) had recurrent disease. Children with cryptosporidiosis presented early, and most had abdominal pain and a short course of diarrhea. Infected children were more likely to carry the human leukocyte antigen (HLA) class II DQB1*0301 allele, particularly those with both asymptomatic and symptomatic infection (P = .009); a strong association was found between carriage of the DQB1*0301/DRB1*1101 haplotype and development of both asymptomatic and symptomatic infection (P = .009). Infected children were also more likely to carry the B*15 HLA class I allele.ConclusionsThis is the first study to describe a possible genetic component of the immune response to Cryptosporidium infection, which includes HLA class I and II alleles. Cryptosporidiosis in Bangladeshi children aged 2-5 year is common and often recurrent, but the duration is shorter and the abdominal pain greater than that described in children aged <2 years."xsd:string |
| http://purl.uniprot.org/citations/18248305 | http://purl.org/dc/terms/identifier | "doi:10.1086/525284"xsd:string |
| http://purl.uniprot.org/citations/18248305 | http://purl.uniprot.org/core/author | "Khan S."xsd:string |
| http://purl.uniprot.org/citations/18248305 | http://purl.uniprot.org/core/author | "Larsson C."xsd:string |
| http://purl.uniprot.org/citations/18248305 | http://purl.uniprot.org/core/author | "Peterson K."xsd:string |
| http://purl.uniprot.org/citations/18248305 | http://purl.uniprot.org/core/author | "Haque R."xsd:string |
| http://purl.uniprot.org/citations/18248305 | http://purl.uniprot.org/core/author | "Petri W.A. Jr."xsd:string |
| http://purl.uniprot.org/citations/18248305 | http://purl.uniprot.org/core/author | "Mondal D."xsd:string |
| http://purl.uniprot.org/citations/18248305 | http://purl.uniprot.org/core/author | "Duggal P."xsd:string |
| http://purl.uniprot.org/citations/18248305 | http://purl.uniprot.org/core/author | "Akter J."xsd:string |
| http://purl.uniprot.org/citations/18248305 | http://purl.uniprot.org/core/author | "Kirkpatrick B.D."xsd:string |
| http://purl.uniprot.org/citations/18248305 | http://purl.uniprot.org/core/author | "Lockhart L."xsd:string |
| http://purl.uniprot.org/citations/18248305 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18248305 | http://purl.uniprot.org/core/name | "J Infect Dis"xsd:string |
| http://purl.uniprot.org/citations/18248305 | http://purl.uniprot.org/core/pages | "474-478"xsd:string |
| http://purl.uniprot.org/citations/18248305 | http://purl.uniprot.org/core/title | "Association between Cryptosporidium infection and human leukocyte antigen class I and class II alleles."xsd:string |
| http://purl.uniprot.org/citations/18248305 | http://purl.uniprot.org/core/volume | "197"xsd:string |
| http://purl.uniprot.org/citations/18248305 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18248305 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-18248305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18248305 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-18248305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18248305 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-18248305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18248305 |