| http://purl.uniprot.org/citations/18249218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18249218 | http://www.w3.org/2000/01/rdf-schema#comment | "RGS2 is a negative regulator of Galpha protein signaling and promotes adipocyte differentiation. Recently, we described a polymorphism at the C1114G locus with the G allele associated with hypertension in a cross-sectional study. The aim of the present study was to assess whether the RGS2 C1114G is predictive of overweight in young subjects with grade I hypertension. We genotyped at the RGS2 C1114G locus 406 (male, n = 294; female, n = 112) white hypertensive subjects (age, 33 +/-9 years) never treated for hypertension and at low cardiovascular risk. Median follow-up was 7.85 years. At baseline, male patients carrying the RGS2 1114G allele had higher body mass index (BMI) than patients with CC genotype (26.1 +/-0.3 vs 25.3 +/-0.3 kg/m2, P < .05). The frequency of male patients with BMI > or = 25 was similar between the patients with G allele and those with CC genotype (55.1% vs 47.8%, P = not significant). No significant difference between the 2 groups was observed with regard to physical activity, blood pressure, and heart rate. At the end of follow-up, BMI was higher in male patients with G allele compared with patients with CC genotype (26.8 +/- 0.3 vs 25.8 +/-0.2 kg/m2, P < .01); and the frequency of male patients with BMI >25 kg/m2 was greater in the former (69.0% vs 52.2%, P < .01). According to Cox regression, allele G was a significant predictor of developing overweight or obesity during follow-up. These epidemiologic relations were not significant in female patients. In young male patients with grade I hypertension, RGS2 1114G allele is associated with increased BMI and with greater risk of developing overweight or obesity. The RGS2 1114G allele may be considered a genetic marker that predicts an individual's predisposition to gaining weight."xsd:string |
| http://purl.uniprot.org/citations/18249218 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.metabol.2007.10.021"xsd:string |
| http://purl.uniprot.org/citations/18249218 | http://purl.uniprot.org/core/author | "Ceolotto G."xsd:string |
| http://purl.uniprot.org/citations/18249218 | http://purl.uniprot.org/core/author | "Sartori M."xsd:string |
| http://purl.uniprot.org/citations/18249218 | http://purl.uniprot.org/core/author | "Mos L."xsd:string |
| http://purl.uniprot.org/citations/18249218 | http://purl.uniprot.org/core/author | "Palatini P."xsd:string |
| http://purl.uniprot.org/citations/18249218 | http://purl.uniprot.org/core/author | "Santonastaso M."xsd:string |
| http://purl.uniprot.org/citations/18249218 | http://purl.uniprot.org/core/author | "Semplicini A."xsd:string |
| http://purl.uniprot.org/citations/18249218 | http://purl.uniprot.org/core/author | "Papparella I."xsd:string |
| http://purl.uniprot.org/citations/18249218 | http://purl.uniprot.org/core/author | "Bratti P."xsd:string |
| http://purl.uniprot.org/citations/18249218 | http://purl.uniprot.org/core/author | "Dorigatti F."xsd:string |
| http://purl.uniprot.org/citations/18249218 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18249218 | http://purl.uniprot.org/core/name | "Metabolism"xsd:string |
| http://purl.uniprot.org/citations/18249218 | http://purl.uniprot.org/core/pages | "421-427"xsd:string |
| http://purl.uniprot.org/citations/18249218 | http://purl.uniprot.org/core/title | "RGS2 C1114G polymorphism and body weight gain in hypertensive patients."xsd:string |
| http://purl.uniprot.org/citations/18249218 | http://purl.uniprot.org/core/volume | "57"xsd:string |
| http://purl.uniprot.org/citations/18249218 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18249218 |
| http://purl.uniprot.org/citations/18249218 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18249218 |
| http://purl.uniprot.org/uniprot/#_P41220-mappedCitation-18249218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18249218 |
| http://purl.uniprot.org/uniprot/#_Q49A86-mappedCitation-18249218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18249218 |
| http://purl.uniprot.org/uniprot/P41220 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18249218 |
| http://purl.uniprot.org/uniprot/Q49A86 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18249218 |