| http://purl.uniprot.org/citations/18250153 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18250153 | http://www.w3.org/2000/01/rdf-schema#comment | "The diverse biological actions of retinoic acid (RA) are mediated by RA receptors (RARs) and retinoid X receptors (RXRs). Modulation of transcription by RARs/RXRs is achieved through two activation functions, ligand-independent AF-1 and ligand-dependent AF-2, located in the A/B and E domains, respectively. While the coregulatory proteins that interact with the E domain are well studied, the A/B domain-interacting partners and their influence(s) on the function of RARs are poorly understood. Acinus-S' is an ubiquitous nuclear protein that has been implicated in inducing apoptotic chromatin condensation and regulating mRNA processing. Our data demonstrate that Acinus-S' can specifically repress ligand-independent and ligand-dependent expression of a DR5 RA response element(RARE)-dependent reporter gene and several endogenous RAR-regulated genes in a dose-dependent and gene-specific manner. Chromatin immunoprecipitation assays show that Acinus-S' associates with RAREs within the promoters of endogenous genes independent of RA treatment. Furthermore, the C-terminal end of Acinus-S' and the B domain of RARbeta interact independently of ligand, and the C-terminal end of Acinus-S' is sufficient for the repression of RAR-regulated gene expression. Finally, histone deacetylase activity only partially accounts for the repressive effect of Acinus-S' on RAR-dependent gene expression. These findings identify Acinus-S' as a novel RAR-interacting protein that regulates the expression of a subset of RAR-regulated genes through direct binding to the N-terminal B domains of RARs."xsd:string |
| http://purl.uniprot.org/citations/18250153 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01199-07"xsd:string |
| http://purl.uniprot.org/citations/18250153 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/18250153 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/18250153 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/18250153 | http://purl.uniprot.org/core/author | "Soprano D.R."xsd:string |
| http://purl.uniprot.org/citations/18250153 | http://purl.uniprot.org/core/author | "Soprano K.J."xsd:string |
| http://purl.uniprot.org/citations/18250153 | http://purl.uniprot.org/core/author | "Vucetic Z."xsd:string |
| http://purl.uniprot.org/citations/18250153 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18250153 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18250153 | http://purl.uniprot.org/core/pages | "2549-2558"xsd:string |
| http://purl.uniprot.org/citations/18250153 | http://purl.uniprot.org/core/title | "Acinus-S' represses retinoic acid receptor (RAR)-regulated gene expression through interaction with the B domains of RARs."xsd:string |
| http://purl.uniprot.org/citations/18250153 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/18250153 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18250153 |
| http://purl.uniprot.org/citations/18250153 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18250153 |
| http://purl.uniprot.org/uniprot/#_A0A286YCX1-mappedCitation-18250153 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18250153 |
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| http://purl.uniprot.org/uniprot/#_A0A286YCH1-mappedCitation-18250153 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18250153 |
| http://purl.uniprot.org/uniprot/#_A0A286YCR2-mappedCitation-18250153 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18250153 |
| http://purl.uniprot.org/uniprot/#_B4DQZ7-mappedCitation-18250153 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18250153 |
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| http://purl.uniprot.org/uniprot/#_B8JJ91-mappedCitation-18250153 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18250153 |