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| http://purl.uniprot.org/citations/18250339 | http://www.w3.org/2000/01/rdf-schema#comment | "Mast cells degranulate and release the contents of intracellular secretory granules in response to the cross-linking of FcepsilonRI by multivalent antigens. These granules contain a variety of biologically active inflammatory mediators; however, it is not clear whether these granules are homogenous or whether there is heterogeneity within the secretory granule population in mast cells. By using genetically altered mice lacking specific vesicle-associated SNARE membrane fusion proteins, we found that VAMP-8-deficient mast cells exhibited defects in FcepsilonRI-regulated exocytosis, whereas synaptobrevin 2- or VAMP-3-deficient mast cells did not. Surprisingly, the defect in secretion in VAMP-8-deficient mice was limited to the subpopulation of mast cell secretory granules containing serotonin and cathepsin D, whereas regulated exocytosis of secretory granules containing histamine and TNF-alpha was normal. Confocal microscopy confirmed that serotonin and histamine were present in distinct intracellular granules and that most serotonin-containing granules were VAMP-8-positive. Thus, this study demonstrates that mast cells do indeed possess distinct subsets of secretory granules and that these subsets use different SNARE isoforms for exocytosis."xsd:string |
| http://purl.uniprot.org/citations/18250339 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0707854105"xsd:string |
| http://purl.uniprot.org/citations/18250339 | http://purl.uniprot.org/core/author | "Puri N."xsd:string |
| http://purl.uniprot.org/citations/18250339 | http://purl.uniprot.org/core/author | "Roche P.A."xsd:string |
| http://purl.uniprot.org/citations/18250339 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18250339 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/18250339 | http://purl.uniprot.org/core/pages | "2580-2585"xsd:string |
| http://purl.uniprot.org/citations/18250339 | http://purl.uniprot.org/core/title | "Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms."xsd:string |
| http://purl.uniprot.org/citations/18250339 | http://purl.uniprot.org/core/volume | "105"xsd:string |
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