| http://purl.uniprot.org/citations/18250471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18250471 | http://www.w3.org/2000/01/rdf-schema#comment | "GM-CSF plays an important role in inflammation by promoting the production, activation, and survival of granulocytes and macrophages. In this study, GM-CSF knockout (GM-CSF(-/-)) mice were used to investigate the role of GM-CSF in a model of allergic airway inflammation. In allergic GM-CSF(-/-) mice, eosinophil recruitment to the airways showed a striking pattern, with eosinophils present in perivascular areas, but almost completely absent in peribronchial areas, whereas in wild-type mice, eosinophil infiltration appeared in both areas. In the GM-CSF(-/-) mice, mucus production in the airways was also reduced, and eosinophil numbers were markedly reduced in the bronchoalveolar lavage (BAL)(3) fluid. IL-5 production was reduced in the lung tissue and BAL fluid of GM-CSF(-/-) mice, but IL-4 and IL-13 production, airway hyperresponsiveness, and serum IgE levels were not affected. The presence of eosinophils in perivascular but not peribronchial regions was suggestive of a cell migration defect in the airways of GM-CSF(-/-) mice. The CCR3 agonists CCL5 (RANTES) and CCL11 (eotaxin-1) were expressed at similar levels in GM-CSF(-/-) and wild-type mice. However, IFN-gamma mRNA and protein were increased in the lung tissue and BAL fluid in GM-CSF(-/-) mice, as were mRNA levels of the IFN-gamma-inducible chemokines CXCL9 (Mig), CXCL10 (IP-10), and CXCL11 (I-Tac). Interestingly, these IFN-gamma-inducible chemokines are natural antagonists of CCR3, suggesting that their overproduction in GM-CSF(-/-) mice contributes to the lack of airway eosinophils. These findings demonstrate distinctive abnormalities to a model of allergic asthma in the absence of GM-CSF."xsd:string |
| http://purl.uniprot.org/citations/18250471 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.180.4.2600"xsd:string |
| http://purl.uniprot.org/citations/18250471 | http://purl.uniprot.org/core/author | "Su Y.C."xsd:string |
| http://purl.uniprot.org/citations/18250471 | http://purl.uniprot.org/core/author | "Mackay C.R."xsd:string |
| http://purl.uniprot.org/citations/18250471 | http://purl.uniprot.org/core/author | "Sewell W.A."xsd:string |
| http://purl.uniprot.org/citations/18250471 | http://purl.uniprot.org/core/author | "Rolph M.S."xsd:string |
| http://purl.uniprot.org/citations/18250471 | http://purl.uniprot.org/core/author | "Hansbro N.G."xsd:string |
| http://purl.uniprot.org/citations/18250471 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18250471 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18250471 | http://purl.uniprot.org/core/pages | "2600-2607"xsd:string |
| http://purl.uniprot.org/citations/18250471 | http://purl.uniprot.org/core/title | "Granulocyte-macrophage colony-stimulating factor is required for bronchial eosinophilia in a murine model of allergic airway inflammation."xsd:string |
| http://purl.uniprot.org/citations/18250471 | http://purl.uniprot.org/core/volume | "180"xsd:string |
| http://purl.uniprot.org/citations/18250471 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18250471 |
| http://purl.uniprot.org/citations/18250471 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18250471 |
| http://purl.uniprot.org/uniprot/#_Q14AD9-mappedCitation-18250471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18250471 |
| http://purl.uniprot.org/uniprot/#_P01587-mappedCitation-18250471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18250471 |
| http://purl.uniprot.org/uniprot/#_Q5SX78-mappedCitation-18250471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18250471 |
| http://purl.uniprot.org/uniprot/Q14AD9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18250471 |
| http://purl.uniprot.org/uniprot/P01587 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18250471 |
| http://purl.uniprot.org/uniprot/Q5SX78 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18250471 |