| http://purl.uniprot.org/citations/18253135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18253135 | http://www.w3.org/2000/01/rdf-schema#comment | "Our objective was to determine if beta(1)-adrenergic receptor (beta(1)-AR) and beta(2)-AR gene polymorphisms influence heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) response to dobutamine during dobutamine stress echocardiography (DSE). Patients (n=163) undergoing clinically indicated DSE were enrolled. Dobutamine doses were titrated from 5 to 40 microg kg(-1) min(-1) at 3 min intervals and HR, SBP and DBP were measured. Genotypes were determined for beta(1)-AR Ser49Gly, beta(1)-AR Arg389Gly, beta(2)-AR Arg16Gly and beta(2)-AR Gln27Glu polymorphisms by polymerase chain reaction-restriction fragment length polymorphism analysis, pyrosequencing and single primer extension methods. beta(2)-AR Glu27 homozygotes had a greater HR response at the highest dobutamine dose than Gln27 carriers (P=0.002). Beta(2)-AR Gly16 homozygotes had a lower HR response during 5-30 microg kg(-1) min(-1) of the dobutamine infusion protocol compared to Arg16 carriers (P=0.03). Differences in SBP by beta(2)-AR codon 16 genotype and DBP by beta(1)-AR codon 389 genotype were found at baseline and were maintained throughout DSE (P=0.06 and 0.02, respectively). However, the magnitude of SBP and DBP response to dobutamine did not differ significantly by beta(2)-AR codon 16 or beta(1)-AR codon 389 genotypes, respectively. These data suggest that the four selected beta(1)- and beta(2)-AR polymorphisms do not substantially influence the magnitude of hemodynamic response to dobutamine during DSE."xsd:string |
| http://purl.uniprot.org/citations/18253135 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.tpj.6500490"xsd:string |
| http://purl.uniprot.org/citations/18253135 | http://purl.uniprot.org/core/author | "Johnson J.A."xsd:string |
| http://purl.uniprot.org/citations/18253135 | http://purl.uniprot.org/core/author | "Cavallari L.H."xsd:string |
| http://purl.uniprot.org/citations/18253135 | http://purl.uniprot.org/core/author | "Lewis J.F."xsd:string |
| http://purl.uniprot.org/citations/18253135 | http://purl.uniprot.org/core/author | "Yarandi H.N."xsd:string |
| http://purl.uniprot.org/citations/18253135 | http://purl.uniprot.org/core/author | "Aquilante C.L."xsd:string |
| http://purl.uniprot.org/citations/18253135 | http://purl.uniprot.org/core/author | "Hamilton K.K."xsd:string |
| http://purl.uniprot.org/citations/18253135 | http://purl.uniprot.org/core/author | "Terra S.G."xsd:string |
| http://purl.uniprot.org/citations/18253135 | http://purl.uniprot.org/core/author | "Andrisin T.E."xsd:string |
| http://purl.uniprot.org/citations/18253135 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18253135 | http://purl.uniprot.org/core/name | "Pharmacogenomics J"xsd:string |
| http://purl.uniprot.org/citations/18253135 | http://purl.uniprot.org/core/pages | "408-415"xsd:string |
| http://purl.uniprot.org/citations/18253135 | http://purl.uniprot.org/core/title | "Beta-adrenergic receptor gene polymorphisms and hemodynamic response to dobutamine during dobutamine stress echocardiography."xsd:string |
| http://purl.uniprot.org/citations/18253135 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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