| http://purl.uniprot.org/citations/18256188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18256188 | http://www.w3.org/2000/01/rdf-schema#comment | "Parkinson's disease (PD) is characterized by a progressive degeneration of substantia nigra dopaminergic neurons projecting to the striatum. Restoration of dopamine transmission by L-DOPA relieves symptoms of PD but causes prominent side effects. There is a strong serotonin innervation of the striatum by serotonergic neurons that remains relatively preserved in PD. The study of this innervation has been largely neglected. Here, we demonstrate that chronic L-DOPA administration to 6-OHDA-lesioned rodents increases, via D1 receptors, the levels of the 5-HT1B receptor and its adaptor protein, p11, in dopamine-denervated striatonigral neurons. Using unilaterally 6-OHDA-lesioned p11 WT and KO mice, it was found that administration of a selective 5-HT1B receptor agonist, CP94253, inhibited L-DOPA-induced rotational behavior and abnormal involuntary movements in a p11-dependent manner. These data reveal an L-DOPA-induced negative-feedback mechanism, whereby the serotonin system may influence the symptomatology of Parkinsonism."xsd:string |
| http://purl.uniprot.org/citations/18256188 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0711839105"xsd:string |
| http://purl.uniprot.org/citations/18256188 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/18256188 | http://purl.uniprot.org/core/author | "Greengard P."xsd:string |
| http://purl.uniprot.org/citations/18256188 | http://purl.uniprot.org/core/author | "Svenningsson P."xsd:string |
| http://purl.uniprot.org/citations/18256188 | http://purl.uniprot.org/core/author | "Andren P.E."xsd:string |
| http://purl.uniprot.org/citations/18256188 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18256188 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/18256188 | http://purl.uniprot.org/core/pages | "2163-2168"xsd:string |
| http://purl.uniprot.org/citations/18256188 | http://purl.uniprot.org/core/title | "Evidence for a role of the 5-HT1B receptor and its adaptor protein, p11, in L-DOPA treatment of an animal model of Parkinsonism."xsd:string |
| http://purl.uniprot.org/citations/18256188 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/18256188 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18256188 |
| http://purl.uniprot.org/citations/18256188 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18256188 |
| http://purl.uniprot.org/uniprot/#_P08207-mappedCitation-18256188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18256188 |
| http://purl.uniprot.org/uniprot/#_P28334-mappedCitation-18256188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18256188 |
| http://purl.uniprot.org/uniprot/#_Q0VES5-mappedCitation-18256188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18256188 |
| http://purl.uniprot.org/uniprot/#_Q3TC45-mappedCitation-18256188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18256188 |
| http://purl.uniprot.org/uniprot/#_Q3UF30-mappedCitation-18256188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18256188 |
| http://purl.uniprot.org/uniprot/P08207 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18256188 |
| http://purl.uniprot.org/uniprot/Q3UF30 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18256188 |
| http://purl.uniprot.org/uniprot/Q3TC45 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18256188 |
| http://purl.uniprot.org/uniprot/P28334 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18256188 |
| http://purl.uniprot.org/uniprot/Q0VES5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18256188 |