| http://purl.uniprot.org/citations/18256252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18256252 | http://www.w3.org/2000/01/rdf-schema#comment | "The cGMP/cGMP-dependent protein kinase I (cGKI) signaling pathway plays an important role in spinal nociceptive processing. However, downstream targets of cGKI in this context have not been identified to date. Using a yeast two-hybrid screen, we isolated cysteine-rich protein 2 (CRP2) as a novel cGKI interactor in the spinal cord. CRP2 is expressed in laminas I and II of the mouse spinal cord and is colocalized with cGKI, calcitonin gene-related peptide, and isolectin B4. Moreover, the majority of CRP2 mRNA-positive dorsal root ganglion (DRG) neurons express cGKI and peripherin. CRP2 is phosphorylated in a cGMP-dependent manner, and its expression increases in the spinal cord and in DRGs after noxious stimulation of a hindpaw. To elucidate the functional role of CRP2 in nociception, we analyzed mice with a targeted deletion of CRP2. CRP2-deficient (CRP2-/-) mice demonstrate normal behavioral responses to acute nociception and after axonal injury of the sciatic nerve, but increased nociceptive behavior in models of inflammatory hyperalgesia compared with wild-type mice. Intrathecal administration of cGMP analogs increases the nociceptive behavior in wild-type but not in CRP2-/-mice, indicating that the presence of CRP2 is important for cGMP-mediated nociception. These data suggest that CRP2 is a new downstream effector of cGKI-mediated spinal nociceptive processing and point to an inhibitory role of CRP2 in the generation of inflammatory pain."xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.5037-07.2008"xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/author | "Gao W."xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/author | "Huber A."xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/author | "Hofmann F."xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/author | "Geisslinger G."xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/author | "Ruth P."xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/author | "Scholich K."xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/author | "Tegeder I."xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/author | "Schmidtko A."xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/author | "Sausbier U."xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/author | "Sausbier M."xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/author | "Allescher H.D."xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/author | "Niederberger E."xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/author | "Neuhuber W."xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/author | "Rauhmeier I."xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/pages | "1320-1330"xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/title | "Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain."xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/18256252 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18256252 |
| http://purl.uniprot.org/citations/18256252 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18256252 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JF37-mappedCitation-18256252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18256252 |