| http://purl.uniprot.org/citations/18256308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18256308 | http://www.w3.org/2000/01/rdf-schema#comment | "Studies in mice with null mutations of adenosine 1 receptor or ecto-5'-nucleotidase genes suggest a critical role of adenosine and its precursor 5'-AMP in tubulovascular signaling. To assess whether the source of juxtaglomerular nucleotides can be traced back to ATP dephosphorylation, experiments were performed in mice with a deficiency in NTPDase1/CD39, an ecto-ATPase catalyzing the formation of AMP from ATP and ADP. Urine osmolarity and glomerular filtration rate (GFR) were indistinguishable between NTPDase1/CD39(-/-) and wild-type (WT) mice. Maximum tubuloglomerular feedback (TGF) responses, as determined by proximal tubular stop flow pressure measurements, were reduced in NTPDase1/CD39(-/-) mice compared with controls (4.2 +/- 0.9 vs. 10.5 +/-1.2 mmHg, respectively; P = 0.0002). Residual TGF responses gradually diminished after repeated changes in tubular perfusion flow averaging 2.9 +/-0.9 (on response) and 3.5 +/-1.1 (off response) mmHg after the second and 2.2 +/-0.5 (on response) and 1.5 +/-0.8 (off response) mmHg after the third challenge, whereas no fading of TGF responsiveness was observed in WT mice. Macula densa-dependent and pressure-dependent inhibition of renin secretion, as assessed by acute salt loading and phenylephrine injection, respectively, were intact in NTPDase1/CD39-deficient mice. In summary, NTPDase1/CD39-deficient mice showed a markedly compromised TGF regulation of GFR. These data support the concept of an extracellular dephosphorylation cascade during tubular-vascular signal transmission in the juxtaglomerular apparatus that is initiated by a regulated release of ATP from macula densa cells and results in adenosine-mediated afferent arteriole constriction."xsd:string |
| http://purl.uniprot.org/citations/18256308 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajprenal.00603.2007"xsd:string |
| http://purl.uniprot.org/citations/18256308 | http://purl.uniprot.org/core/author | "Oppermann M."xsd:string |
| http://purl.uniprot.org/citations/18256308 | http://purl.uniprot.org/core/author | "Enjyoji K."xsd:string |
| http://purl.uniprot.org/citations/18256308 | http://purl.uniprot.org/core/author | "Friedman D.J."xsd:string |
| http://purl.uniprot.org/citations/18256308 | http://purl.uniprot.org/core/author | "Robson S.C."xsd:string |
| http://purl.uniprot.org/citations/18256308 | http://purl.uniprot.org/core/author | "Castrop H."xsd:string |
| http://purl.uniprot.org/citations/18256308 | http://purl.uniprot.org/core/author | "Schnermann J."xsd:string |
| http://purl.uniprot.org/citations/18256308 | http://purl.uniprot.org/core/author | "Faulhaber-Walter R."xsd:string |
| http://purl.uniprot.org/citations/18256308 | http://purl.uniprot.org/core/author | "Mizel D."xsd:string |
| http://purl.uniprot.org/citations/18256308 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18256308 | http://purl.uniprot.org/core/name | "Am J Physiol Renal Physiol"xsd:string |
| http://purl.uniprot.org/citations/18256308 | http://purl.uniprot.org/core/pages | "F965-70"xsd:string |
| http://purl.uniprot.org/citations/18256308 | http://purl.uniprot.org/core/title | "Tubuloglomerular feedback and renin secretion in NTPDase1/CD39-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/18256308 | http://purl.uniprot.org/core/volume | "294"xsd:string |
| http://purl.uniprot.org/citations/18256308 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18256308 |
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| http://purl.uniprot.org/uniprot/#_Q8CEB1-mappedCitation-18256308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18256308 |