| http://purl.uniprot.org/citations/18256700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18256700 | http://www.w3.org/2000/01/rdf-schema#comment | "Cystatins are a family of naturally occurring cysteine protease inhibitors, yet the target proteases and biological processes they regulate are poorly understood. Cystatin F is expressed selectively in immune cells and is the only cystatin to be synthesised as an inactive disulphide-linked dimeric precursor. Here, we show that a major target of cystatin F in different immune cell types is the aminopeptidase cathepsin C, which regulates the activation of effector serine proteases in T cells, natural killer cells, neutrophils and mast cells. Surprisingly, recombinant cystatin F was unable to inhibit cathepsin C in vitro even though overexpression of cystatin F suppressed cellular cathepsin C activity. We predicted, using structural models, that an N-terminal processing event would be necessary before cystatin F can engage cathepsin C and we show that the intracellular form of cystatin F indeed has a precise N-terminal truncation that creates a cathepsin C inhibitor. Thus, cystatin F is a latent protease inhibitor itself regulated by proteolysis in the endocytic pathway. By targeting cathepsin C, it may regulate diverse immune cell effector functions."xsd:string |
| http://purl.uniprot.org/citations/18256700 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601979"xsd:string |
| http://purl.uniprot.org/citations/18256700 | http://purl.uniprot.org/core/author | "Schuettelkopf A.W."xsd:string |
| http://purl.uniprot.org/citations/18256700 | http://purl.uniprot.org/core/author | "Watts C."xsd:string |
| http://purl.uniprot.org/citations/18256700 | http://purl.uniprot.org/core/author | "Hamilton G."xsd:string |
| http://purl.uniprot.org/citations/18256700 | http://purl.uniprot.org/core/author | "Colbert J.D."xsd:string |
| http://purl.uniprot.org/citations/18256700 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18256700 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/18256700 | http://purl.uniprot.org/core/pages | "499-508"xsd:string |
| http://purl.uniprot.org/citations/18256700 | http://purl.uniprot.org/core/title | "Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis."xsd:string |
| http://purl.uniprot.org/citations/18256700 | http://purl.uniprot.org/core/volume | "27"xsd:string |
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