| http://purl.uniprot.org/citations/18258299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18258299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18258299 | http://www.w3.org/2000/01/rdf-schema#comment | "Proteomic effect screening in zebrafish liver was performed to generate hypotheses following exposure (21 days) to a structurally diverse mixture of brominated flame retardants (BFRs). Fish were exposed to two doses (10 and 100 nmol/g feed). Two-dimensional gel-electrophoresis, image analysis and MALDI-TOF mass-spectrometry revealed 13 and 19 significant responses in males and females, respectively. Effects on proteins related to cellular maintenance and stress were observed in both genders. Regulated proteins were gender-specific, but functionally indicated common protective responses (peroxiredoxin 6 and Zgc:92891 in males and transketolase in females) suggesting oxidative stress. Betaine homocysteine methyltransferase (BHMT) was induced in both genders. In addition a female-specific downregulation of ironhomeostatic proteins (iron-regulatory protein 1 and transferrin) were observed. Our proteomic approach revealed novel responses that suggest important gender-specific sensitivity to BFRs that should be considered when interpreting adverse effects of BFRs."xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ecoenv.2007.12.010"xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/author | "Norman A."xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/author | "Norman A."xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/author | "Kling P."xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/author | "Kling P."xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/author | "Andersson P.L."xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/author | "Andersson P.L."xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/author | "Forlin L."xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/author | "Forlin L."xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/author | "Norrgren L."xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/author | "Norrgren L."xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/name | "Ecotoxicol. Environ. Saf."xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/name | "Ecotoxicol Environ Saf"xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/pages | "319-327"xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/pages | "319-327"xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/title | "Gender-specific proteomic responses in zebrafish liver following exposure to a selected mixture of brominated flame retardants."xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/title | "Gender-specific proteomic responses in zebrafish liver following exposure to a selected mixture of brominated flame retardants."xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/volume | "71"xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://purl.uniprot.org/core/volume | "71"xsd:string |
| http://purl.uniprot.org/citations/18258299 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18258299 |