| http://purl.uniprot.org/citations/18258592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18258592 | http://www.w3.org/2000/01/rdf-schema#comment | "Sortilin has been implicated in the formation of insulin-responsive GLUT4 storage vesicles in adipocytes by regulating sorting events between the trans-Golgi-network and endosomes. We herein show that sortilin serves as a potent myogenic differentiation stimulator for C2C12 myocytes by cooperatively functioning with p75NTR, which subsequently further contributes to development of the insulin-responsive glucose transport system in C2C12 myotubes. Sortilin expression was up-regulated upon C2C12 differentiation, and overexpression of sortilin in C2C12 cells significantly stimulated myogenic differentiation, a response that was completely abolished by either anti-p75NTR- or anti-nerve growth factor (NGF)-neutralizing antibodies. Importantly, small interference RNA-mediated suppression of endogenous sortilin significantly inhibited C2C12 differentiation, indicating the physiological significance of sortilin expression in the process of myogenesis. Although sortilin overexpression in C2C12 myotubes improved insulin-induced 2-deoxyglucose uptake, as previously reported, this effect apparently resulted from a decrease in the cellular content of GLUT1 and an increase in GLUT4 via differentiation-dependent alterations at both the gene transcriptional and the post-translational level. In addition, cellular contents of Ubc9 and SUMO-modified proteins appeared to be increased by sortilin overexpression. Taken together, these data demonstrate that sortilin is involved not only in development of the insulin-responsive glucose transport system in myocytes, but is also directly involved in muscle differentiation via modulation of proNGF-p75NTR."xsd:string |
| http://purl.uniprot.org/citations/18258592 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m710604200"xsd:string |
| http://purl.uniprot.org/citations/18258592 | http://purl.uniprot.org/core/author | "Katagiri H."xsd:string |
| http://purl.uniprot.org/citations/18258592 | http://purl.uniprot.org/core/author | "Nedachi T."xsd:string |
| http://purl.uniprot.org/citations/18258592 | http://purl.uniprot.org/core/author | "Kanzaki M."xsd:string |
| http://purl.uniprot.org/citations/18258592 | http://purl.uniprot.org/core/author | "Ariga M."xsd:string |
| http://purl.uniprot.org/citations/18258592 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18258592 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18258592 | http://purl.uniprot.org/core/pages | "10208-10220"xsd:string |
| http://purl.uniprot.org/citations/18258592 | http://purl.uniprot.org/core/title | "Functional role of sortilin in myogenesis and development of insulin-responsive glucose transport system in C2C12 myocytes."xsd:string |
| http://purl.uniprot.org/citations/18258592 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18258592 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18258592 |
| http://purl.uniprot.org/citations/18258592 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18258592 |
| http://purl.uniprot.org/uniprot/Q99523#attribution-1EA368B8E45C92CA97D781692608E2F2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18258592 |
| http://purl.uniprot.org/uniprot/Q6PHU5#attribution-1EA368B8E45C92CA97D781692608E2F2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18258592 |
| http://purl.uniprot.org/uniprot/#_Q6PHU5-mappedCitation-18258592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18258592 |
| http://purl.uniprot.org/uniprot/Q6PHU5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18258592 |