| http://purl.uniprot.org/citations/18258846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18258846 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous work has shown that integrin alpha1-null Alport mice exhibit attenuated glomerular disease with decreased matrix accumulation and live much longer than strain-matched Alport mice. However, the mechanism underlying this observation is unknown. Here we show that glomerular gelatinase expression, specifically matrix metalloproteinase-2 (MMP-2), MMP-9, and MMP-14, was significantly elevated in both integrin alpha1-null mice and integrin alpha1-null Alport mice relative to wild-type mice; however, only MMP-9 was elevated in glomeruli of Alport mice that express integrin alpha1. Similarly, cultured mesangial cells from alpha1-null mice showed elevated expression levels of all three MMPs, whereas mesangial cells from Alport mice show elevated expression levels of only MMP-9. In both glomeruli and cultured mesangial cells isolated from integrin alpha1-null mice, activation of the p38 and ERK branches of the mitogen-activated protein kinase pathway was also observed. The use of small molecule inhibitors demonstrated that the activation of the p38, but not ERK, pathway was linked to elevated MMP-2, -9, and -14 expression levels in mesangial cells from integrin alpha1-null mice. In contrast, elevated MMP-9 levels in mesangial cells from Alport mice were linked to ERK pathway activation. Blockade of gelatinase activity using a small molecule inhibitor (BAY-12-9566) ameliorated progression of proteinuria and restored the architecture of the glomerular basement membrane in alpha1 integrin-null Alport mice, suggesting that elevated gelatinase activity exacerbates glomerular disease progression in these mice."xsd:string |
| http://purl.uniprot.org/citations/18258846 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2008.070473"xsd:string |
| http://purl.uniprot.org/citations/18258846 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/18258846 | http://purl.uniprot.org/core/author | "Meehan D.T."xsd:string |
| http://purl.uniprot.org/citations/18258846 | http://purl.uniprot.org/core/author | "Rao V.H."xsd:string |
| http://purl.uniprot.org/citations/18258846 | http://purl.uniprot.org/core/author | "Cosgrove D."xsd:string |
| http://purl.uniprot.org/citations/18258846 | http://purl.uniprot.org/core/author | "Pozzi A."xsd:string |
| http://purl.uniprot.org/citations/18258846 | http://purl.uniprot.org/core/author | "Delimont D."xsd:string |
| http://purl.uniprot.org/citations/18258846 | http://purl.uniprot.org/core/author | "Zallocchi M."xsd:string |
| http://purl.uniprot.org/citations/18258846 | http://purl.uniprot.org/core/author | "Tempero R.M."xsd:string |
| http://purl.uniprot.org/citations/18258846 | http://purl.uniprot.org/core/author | "Rodgers K.D."xsd:string |
| http://purl.uniprot.org/citations/18258846 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18258846 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/18258846 | http://purl.uniprot.org/core/pages | "761-773"xsd:string |
| http://purl.uniprot.org/citations/18258846 | http://purl.uniprot.org/core/title | "Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells: implications for Alport syndrome."xsd:string |
| http://purl.uniprot.org/citations/18258846 | http://purl.uniprot.org/core/volume | "172"xsd:string |
| http://purl.uniprot.org/citations/18258846 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18258846 |
| http://purl.uniprot.org/citations/18258846 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18258846 |
| http://purl.uniprot.org/uniprot/#_F6RIS8-mappedCitation-18258846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18258846 |
| http://purl.uniprot.org/uniprot/#_Q3V391-mappedCitation-18258846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18258846 |
| http://purl.uniprot.org/uniprot/#_Q3V3R4-mappedCitation-18258846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18258846 |
| http://purl.uniprot.org/uniprot/#_M0QWQ2-mappedCitation-18258846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18258846 |
| http://purl.uniprot.org/uniprot/#_Q9QZS0-mappedCitation-18258846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18258846 |
| http://purl.uniprot.org/uniprot/#_Q05DI0-mappedCitation-18258846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18258846 |