| http://purl.uniprot.org/citations/18258917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18258917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18258917 | http://www.w3.org/2000/01/rdf-schema#comment | "Mouse CD4+CD8+ double-positive (DP) thymocytes differentiate into CD4+ helper-lineage cells upon expression of the transcription factor Th-POK but commit to the CD8+ cytotoxic lineage in its absence. We report the redirected differentiation of class I-restricted thymocytes into CD4+CD8-helper-like T cells upon loss of Runx transcription factor complexes. A Runx-binding sequence within the Th-POK locus acts as a transcriptional silencer that is essential for Th-POK repression and for development of CD8+ T cells. Thus, Th-POK expression and genetic programming for T helper cell development are actively inhibited by Runx-dependent silencer activity, allowing for cytotoxic T cell differentiation. Identification of the transcription factors network in CD4 and CD8 lineage choice provides insight into how distinct T cell subsets are developed for regulating the adaptive immune system."xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1151844"xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1151844"xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/author | "Akiyama K."xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/author | "Akiyama K."xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/author | "Tachibana M."xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/author | "Tachibana M."xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/author | "Muroi S."xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/author | "Muroi S."xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/author | "Okuda T."xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/author | "Okuda T."xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/author | "Naoe Y."xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/author | "Naoe Y."xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/author | "Taniuchi I."xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/author | "Taniuchi I."xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/author | "Setoguchi R."xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/author | "Setoguchi R."xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/author | "Tezuka C."xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/author | "Tezuka C."xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/18258917 | http://purl.uniprot.org/core/name | "Science"xsd:string |