| http://purl.uniprot.org/citations/18264109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18264109 | http://www.w3.org/2000/01/rdf-schema#comment | "Infections by attaching and effacing (A/E) bacterial pathogens, such as Escherichia coli O157:H7, pose a serious threat to public health. Using a mouse A/E pathogen, Citrobacter rodentium, we show that interleukin-22 (IL-22) has a crucial role in the early phase of host defense against C. rodentium. Infection of IL-22 knockout mice results in increased intestinal epithelial damage, systemic bacterial burden and mortality. We also find that IL-23 is required for the early induction of IL-22 during C. rodentium infection, and adaptive immunity is not essential for the protective role of IL-22 in this model. Instead, IL-22 is required for the direct induction of the Reg family of antimicrobial proteins, including RegIIIbeta and RegIIIgamma, in colonic epithelial cells. Exogenous mouse or human RegIIIgamma substantially improves survival of IL-22 knockout mice after C. rodentium infection. Together, our data identify a new innate immune function for IL-22 in regulating early defense mechanisms against A/E bacterial pathogens."xsd:string |
| http://purl.uniprot.org/citations/18264109 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm1720"xsd:string |
| http://purl.uniprot.org/citations/18264109 | http://purl.uniprot.org/core/author | "Gong Q."xsd:string |
| http://purl.uniprot.org/citations/18264109 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/18264109 | http://purl.uniprot.org/core/author | "Zheng Y."xsd:string |
| http://purl.uniprot.org/citations/18264109 | http://purl.uniprot.org/core/author | "Modrusan Z."xsd:string |
| http://purl.uniprot.org/citations/18264109 | http://purl.uniprot.org/core/author | "Ghilardi N."xsd:string |
| http://purl.uniprot.org/citations/18264109 | http://purl.uniprot.org/core/author | "de Sauvage F.J."xsd:string |
| http://purl.uniprot.org/citations/18264109 | http://purl.uniprot.org/core/author | "Ouyang W."xsd:string |
| http://purl.uniprot.org/citations/18264109 | http://purl.uniprot.org/core/author | "Valdez P.A."xsd:string |
| http://purl.uniprot.org/citations/18264109 | http://purl.uniprot.org/core/author | "Danilenko D.M."xsd:string |
| http://purl.uniprot.org/citations/18264109 | http://purl.uniprot.org/core/author | "Sa S.M."xsd:string |
| http://purl.uniprot.org/citations/18264109 | http://purl.uniprot.org/core/author | "Abbas A.R."xsd:string |
| http://purl.uniprot.org/citations/18264109 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18264109 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/18264109 | http://purl.uniprot.org/core/pages | "282-289"xsd:string |
| http://purl.uniprot.org/citations/18264109 | http://purl.uniprot.org/core/title | "Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens."xsd:string |
| http://purl.uniprot.org/citations/18264109 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/18264109 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18264109 |
| http://purl.uniprot.org/citations/18264109 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18264109 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF4-mappedCitation-18264109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18264109 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0P4-mappedCitation-18264109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18264109 |
| http://purl.uniprot.org/uniprot/#_E9Q9A6-mappedCitation-18264109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18264109 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SW88-mappedCitation-18264109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18264109 |