| http://purl.uniprot.org/citations/18264113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18264113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18264113 | http://www.w3.org/2000/01/rdf-schema#comment | "Histone modifications have important roles in transcriptional control, mitosis and heterochromatin formation. G9a and G9a-like protein (GLP) are euchromatin-associated methyltransferases that repress transcription by mono- and dimethylating histone H3 at Lys9 (H3K9). Here we demonstrate that the ankyrin repeat domains of G9a and GLP bind with strong preference to N-terminal H3 peptides containing mono- or dimethyl K9. X-ray crystallography revealed the basis for recognition of the methylated lysine by a partial hydrophobic cage with three tryptophans and one acidic residue. Substitution of key residues in the cage eliminated the H3 tail interaction. Hence, G9a and GLP contain a new type of methyllysine binding module (the ankyrin repeat domains) and are the first examples of protein (histone) methyltransferases harboring in a single polypeptide the activities that generate and read the same epigenetic mark."xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.1384"xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.1384"xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/author | "Cheng X."xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/author | "Cheng X."xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/author | "Horton J.R."xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/author | "Horton J.R."xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/author | "Lee D.Y."xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/author | "Lee D.Y."xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/author | "Stallcup M.R."xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/author | "Stallcup M.R."xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/author | "Collins R.E."xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/author | "Collins R.E."xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/author | "Northrop J.P."xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/author | "Northrop J.P."xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/pages | "245-250"xsd:string |
| http://purl.uniprot.org/citations/18264113 | http://purl.uniprot.org/core/pages | "245-250"xsd:string |