| http://purl.uniprot.org/citations/18264952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18264952 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo examine the distribution of placental growth factor (PlGF), vascular endothelial growth factor (VEGF) and soluble VEGF receptor-1 (sFlt-1) in maternal and embryonic fluid compartments in early pregnancy.MethodThe concentrations of PlGF, VEGF and sFlt-1 were measured in coelomic fluid and maternal serum from 16 singleton pregnancies at 7.0-9.3 weeks. In six cases, amniotic fluid was also examined.ResultsThe median concentration of PlGF was 14.1 (range 8.9-27.6) pg/mL in maternal serum, 13.9 (range 9.5-31.4) pg/mL in coelomic fluid and 8.9 (range 3.9-15.3) pg/mL in amniotic fluid. The concentration of PlGF increased between 7.0 and 9.3 weeks in maternal serum (p = 0.001) and decreased in coelomic and amniotic fluid (p = 0.001). The median concentration of sFlt-1 was 8561 (range 6724-10 673) pg/mL in coelomic fluid, 523 (range 244-986) pg/mL in maternal serum, 30 (range 12-83) pg/mL in amniotic fluid (p = 0.0001), and it did not change significantly with gestation. VEGF was undetectable in most of the samples, and therefore, no further analysis was performed.ConclusionPlGF and sFlt-1 are present in the maternal and fetal fluid compartments in very early pregnancy, and their distribution is consistent with their site of production and the local conditions of transport."xsd:string |
| http://purl.uniprot.org/citations/18264952 | http://purl.org/dc/terms/identifier | "doi:10.1002/pd.1916"xsd:string |
| http://purl.uniprot.org/citations/18264952 | http://purl.uniprot.org/core/author | "Spencer K."xsd:string |
| http://purl.uniprot.org/citations/18264952 | http://purl.uniprot.org/core/author | "Nicolaides K.H."xsd:string |
| http://purl.uniprot.org/citations/18264952 | http://purl.uniprot.org/core/author | "Savvidou M.D."xsd:string |
| http://purl.uniprot.org/citations/18264952 | http://purl.uniprot.org/core/author | "Sotiriadis A."xsd:string |
| http://purl.uniprot.org/citations/18264952 | http://purl.uniprot.org/core/author | "Makrydimas G."xsd:string |
| http://purl.uniprot.org/citations/18264952 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18264952 | http://purl.uniprot.org/core/name | "Prenat Diagn"xsd:string |
| http://purl.uniprot.org/citations/18264952 | http://purl.uniprot.org/core/pages | "175-179"xsd:string |
| http://purl.uniprot.org/citations/18264952 | http://purl.uniprot.org/core/title | "Physiological distribution of placental growth factor and soluble Flt-1 in early pregnancy."xsd:string |
| http://purl.uniprot.org/citations/18264952 | http://purl.uniprot.org/core/volume | "28"xsd:string |
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