| http://purl.uniprot.org/citations/18265927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18265927 | http://www.w3.org/2000/01/rdf-schema#comment | "Mice deficient in lysyl oxidase-like1 protein (LOXL1(-/-)) develop pelvic organ prolapse (POP). We sought to determine the impact of LOXL1(-/-) on the biomechanical properties of the vagina and its supportive tissues tested as a complex. Tissues of nulliparous LOXL1(-/-) and age-matched wild type (WT) mice were tested to failure to obtain load-distension curves. Data were compared utilizing one-way analysis of variance and appropriate post hoc tests. The groups demonstrated different biomechanical behavior, with LOXL1(-/-) animals displaying a 31% decrease in ultimate load at failure (p=0.001). Experimental disruption of specific levels of support in WT mice failed to generate load-distension curves similar to the LOXL1(-/-) mice indicating a global instead of a site-specific tissue defect. The decrease in the ultimate load at failure in the LOXL1(-/-) mice suggests mechanically weaker tissues. LOXL1 mutation results in a global defect in connective tissues and correlates with altered biomechanical behavior of the vagina and supportive tissues."xsd:string |
| http://purl.uniprot.org/citations/18265927 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00192-008-0561-7"xsd:string |
| http://purl.uniprot.org/citations/18265927 | http://purl.uniprot.org/core/author | "Moalli P.A."xsd:string |
| http://purl.uniprot.org/citations/18265927 | http://purl.uniprot.org/core/author | "Meyn L."xsd:string |
| http://purl.uniprot.org/citations/18265927 | http://purl.uniprot.org/core/author | "Abramowitch S."xsd:string |
| http://purl.uniprot.org/citations/18265927 | http://purl.uniprot.org/core/author | "Alperin M."xsd:string |
| http://purl.uniprot.org/citations/18265927 | http://purl.uniprot.org/core/author | "Debes K."xsd:string |
| http://purl.uniprot.org/citations/18265927 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18265927 | http://purl.uniprot.org/core/name | "Int Urogynecol J Pelvic Floor Dysfunct"xsd:string |
| http://purl.uniprot.org/citations/18265927 | http://purl.uniprot.org/core/pages | "977-986"xsd:string |
| http://purl.uniprot.org/citations/18265927 | http://purl.uniprot.org/core/title | "LOXL1 deficiency negatively impacts the biomechanical properties of the mouse vagina and supportive tissues."xsd:string |
| http://purl.uniprot.org/citations/18265927 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/18265927 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18265927 |
| http://purl.uniprot.org/citations/18265927 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18265927 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0Q4-mappedCitation-18265927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18265927 |
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| http://purl.uniprot.org/uniprot/#_P97873-mappedCitation-18265927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18265927 |
| http://purl.uniprot.org/uniprot/P97873 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18265927 |
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| http://purl.uniprot.org/uniprot/A0A0R4J0Q4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18265927 |