| http://purl.uniprot.org/citations/18266910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18266910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18266910 | http://www.w3.org/2000/01/rdf-schema#comment | "The centrosome-nucleus attachment is a prerequisite for faithful chromosome segregation during mitosis. We addressed the function of the nuclear envelope (NE) protein Sun-1 in centrosome-nucleus connection and the maintenance of genome stability in Dictyostelium discoideum. We provide evidence that Sun-1 requires direct chromatin binding for its inner nuclear membrane targeting. Truncation of the cryptic N-terminal chromatin-binding domain of Sun-1 induces dramatic separation of the inner from the outer nuclear membrane and deformations in nuclear morphology, which are also observed using a Sun-1 RNAi construct. Thus, chromatin binding of Sun-1 defines the integrity of the nuclear architecture. In addition to its role as a NE scaffold, we find that abrogation of the chromatin binding of Sun-1 dissociates the centrosome-nucleus connection, demonstrating that Sun-1 provides an essential link between the chromatin and the centrosome. Moreover, loss of the centrosome-nucleus connection causes severe centrosome hyperamplification and defective spindle formation, which enhances aneuploidy and cell death significantly. We highlight an important new aspect for Sun-1 in coupling the centrosome and nuclear division during mitosis to ensure faithful chromosome segregation."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1600-0854.2008.00721.x"xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1600-0854.2008.00721.x"xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/author | "Xiong H."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/author | "Xiong H."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/author | "Noegel A.A."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/author | "Noegel A.A."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/author | "Rivero F."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/author | "Rivero F."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/author | "Euteneuer U."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/author | "Euteneuer U."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/author | "Gassen B."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/author | "Gassen B."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/author | "Larochelle D."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/author | "Larochelle D."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/author | "Mana-Capelli S."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/author | "Mana-Capelli S."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/author | "Mondal S."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/author | "Mondal S."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/author | "Vogel A."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/author | "Vogel A."xsd:string |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18266910 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |