| http://purl.uniprot.org/citations/18267071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18267071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18267071 | http://www.w3.org/2000/01/rdf-schema#comment | "Ghrelin is a 28 amino acid, appetite-stimulating peptide hormone secreted by the food-deprived stomach. Serine-3 of ghrelin is acylated with an eight-carbon fatty acid, octanoate, which is required for its endocrine actions. Here, we identify GOAT (Ghrelin O-Acyltransferase), a polytopic membrane-bound enzyme that attaches octanoate to serine-3 of ghrelin. Analysis of the mouse genome revealed that GOAT belongs to a family of 16 hydrophobic membrane-bound acyltransferases that includes Porcupine, which attaches long-chain fatty acids to Wnt proteins. GOAT is the only member of this family that octanoylates ghrelin when coexpressed in cultured endocrine cell lines with prepro-ghrelin. GOAT activity requires catalytic asparagine and histidine residues that are conserved in this family. Consistent with its function, GOAT mRNA is largely restricted to stomach and intestine, the major ghrelin-secreting tissues. Identification of GOAT will facilitate the search for inhibitors that reduce appetite and diminish obesity in humans."xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2008.01.017"xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2008.01.017"xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/author | "Grishin N.V."xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/author | "Grishin N.V."xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/author | "Brown M.S."xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/author | "Brown M.S."xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/author | "Goldstein J.L."xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/author | "Goldstein J.L."xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/author | "Liang G."xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/author | "Liang G."xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/pages | "387-396"xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/pages | "387-396"xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/title | "Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone."xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/title | "Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone."xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/volume | "132"xsd:string |
| http://purl.uniprot.org/citations/18267071 | http://purl.uniprot.org/core/volume | "132"xsd:string |