| http://purl.uniprot.org/citations/18268320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18268320 | http://www.w3.org/2000/01/rdf-schema#comment | "The secreted Bv8 protein has been recently characterized as a regulator of myeloid cell mobilization and a neutrophil-derived mediator of tumor angiogenesis in several xenografts, but its role in tumor progression in an endogenous setting was unknown. The rat insulin promoter (RIP)-T-antigen (Tag) is a well characterized transgenic mouse model of multistage pancreatic beta-cell tumorigenesis. Also, the role of neutrophils in RIP-Tag angiogenic switching, as assessed by systemic ablation using anti-Gr1 antibodies at different stages of tumor progression, has been recently described. Here, we show that early treatment of RIP-Tag mice with anti-Bv8 antibodies resulted in a significant reduction in the number of angiogenic islets relative to control antibody-treated mice, implicating Bv8 in the angiogenic switch during neoplasia. Histological analysis showed a significant reduction in vascular surface areas in hyperplastic and angiogenic lesions in pancreatic islets from anti-Bv8-treated mice. Anti-Bv8 treatment also inhibited the mobilization and homing of CD11b+Gr1+ cells to the peripheral blood and the emerging neoplastic lesions. However, anti-Bv8 treatment had no effect on tumor vascularization or burden when initiated at later stages of tumor progression. The stage-dependent efficacy of anti-Bv8 treatment appears remarkably similar to that reported after neutrophil ablation, suggesting that Bv8 is an important mediator of neutrophil-dependent angiogenesis in this transgenic model. In summary, our studies verify a role for Bv8 in the mobilization and recruitment of myeloid cells and in the induction of tumor angiogenesis in the early stages of neoplastic progression."xsd:string |
| http://purl.uniprot.org/citations/18268320 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0712185105"xsd:string |
| http://purl.uniprot.org/citations/18268320 | http://purl.uniprot.org/core/author | "Singh M."xsd:string |
| http://purl.uniprot.org/citations/18268320 | http://purl.uniprot.org/core/author | "Ferrara N."xsd:string |
| http://purl.uniprot.org/citations/18268320 | http://purl.uniprot.org/core/author | "Thompson J.D."xsd:string |
| http://purl.uniprot.org/citations/18268320 | http://purl.uniprot.org/core/author | "Shojaei F."xsd:string |
| http://purl.uniprot.org/citations/18268320 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18268320 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/18268320 | http://purl.uniprot.org/core/pages | "2640-2645"xsd:string |
| http://purl.uniprot.org/citations/18268320 | http://purl.uniprot.org/core/title | "Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression."xsd:string |
| http://purl.uniprot.org/citations/18268320 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/18268320 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18268320 |
| http://purl.uniprot.org/citations/18268320 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18268320 |
| http://purl.uniprot.org/uniprot/#_Q14AB2-mappedCitation-18268320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18268320 |
| http://purl.uniprot.org/uniprot/#_G3X8R6-mappedCitation-18268320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18268320 |
| http://purl.uniprot.org/uniprot/#_Q9QXU7-mappedCitation-18268320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18268320 |
| http://purl.uniprot.org/uniprot/G3X8R6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18268320 |
| http://purl.uniprot.org/uniprot/Q14AB2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18268320 |
| http://purl.uniprot.org/uniprot/Q9QXU7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18268320 |