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http://purl.uniprot.org/citations/18269586http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18269586http://www.w3.org/2000/01/rdf-schema#comment"

Aims

Neural (N)-cadherin belongs to a group of transmembrane molecules with a crucial role in tissue morphogenesis and maintenance of an epithelioid phenotype and increased N-cadherin expression is implicated in tumour progression and dedifferentiation. The aim was to determine whether evaluation of N-cadherin in pulmonary tumours might assist in identifying lesions with more aggressive potential.

Methods and results

One hundred and fifty-five pulmonary lesions were analysed for N-cadherin expression using immunohistochemistry, including neuroendocrine hyperplasia (n = 3), typical carcinoid (n = 59), atypical carcinoid (n = 12), small cell lung carcinoma (n = 11), large cell neuroendocrine carcinoma (n = 12), adenocarcinoma (n = 35) and squamous cell carcinoma (n = 23). Lymph node status was correlated with immunohistochemical expression. N-cadherin expression was demonstrated in all cases of neuroendocrine hyperplasia, 96% of typical carcinoids, 83% of atypical carcinoids, 63% of the small cell lung carcinomas and 32% of large cell neuroendocrine carcinomas. Over 90% of the adenocarcinomas and 100% of the squamous cell carcinomas were negative. Increased N-cadherin expression in typical carcinoids was associated with negative lymph node status (P < 0.001).

Discussion

N-cadherin is differentially expressed in pulmonary tumours and is predominantly observed in neuroendocrine lung lesions with high expression in typical and atypical pulmonary carcinoids. The level of expression of N-cadherin between types of lung tumours does not appear to indicate malignant potential or aggressive behaviour."xsd:string
http://purl.uniprot.org/citations/18269586http://purl.org/dc/terms/identifier"doi:10.1111/j.1365-2559.2007.02952.x"xsd:string
http://purl.uniprot.org/citations/18269586http://purl.uniprot.org/core/author"Yeldandi A.V."xsd:string
http://purl.uniprot.org/citations/18269586http://purl.uniprot.org/core/author"Ho L.C."xsd:string
http://purl.uniprot.org/citations/18269586http://purl.uniprot.org/core/author"Laskin W.B."xsd:string
http://purl.uniprot.org/citations/18269586http://purl.uniprot.org/core/author"Zynger D.L."xsd:string
http://purl.uniprot.org/citations/18269586http://purl.uniprot.org/core/author"Dimov N.D."xsd:string
http://purl.uniprot.org/citations/18269586http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18269586http://purl.uniprot.org/core/name"Histopathology"xsd:string
http://purl.uniprot.org/citations/18269586http://purl.uniprot.org/core/pages"348-354"xsd:string
http://purl.uniprot.org/citations/18269586http://purl.uniprot.org/core/title"Differential expression of neural-cadherin in pulmonary epithelial tumours."xsd:string
http://purl.uniprot.org/citations/18269586http://purl.uniprot.org/core/volume"52"xsd:string
http://purl.uniprot.org/citations/18269586http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18269586
http://purl.uniprot.org/citations/18269586http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18269586
http://purl.uniprot.org/uniprot/#_C9J126-mappedCitation-18269586http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18269586
http://purl.uniprot.org/uniprot/#_P19022-mappedCitation-18269586http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18269586
http://purl.uniprot.org/uniprot/P19022http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18269586
http://purl.uniprot.org/uniprot/C9J126http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18269586