| http://purl.uniprot.org/citations/18270588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18270588 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundMechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance remains incomplete. We characterize the role of p38 mitogen-activated protein kinase/mitogen activated protein kinase kinase-3 and c-Jun-NH(2)-terminal kinase-1 in ventilator-induced lung injury and investigate novel independent mechanisms contributing to lung injury during mechanical ventilation.Methodology and principle findingsC57/BL6 wild-type mice and mice genetically deleted for mitogen-activated protein kinase kinase-3 (mkk-3(-/-)) or c-Jun-NH(2)-terminal kinase-1 (jnk1(-/-)) were ventilated, and lung injury parameters were assessed. We demonstrate that mkk3(-/-) or jnk1(-/-) mice displayed significantly reduced inflammatory lung injury and apoptosis relative to wild-type mice. Since jnk1(-/-) mice were highly resistant to ventilator-induced lung injury, we performed comprehensive gene expression profiling of ventilated wild-type or jnk1(-/-) mice to identify novel candidate genes which may play critical roles in the pathogenesis of ventilator-induced lung injury. Microarray analysis revealed many novel genes differentially expressed by ventilation including matrix metalloproteinase-8 (MMP8) and GADD45alpha. Functional characterization of MMP8 revealed that mmp8(-/-) mice were sensitized to ventilator-induced lung injury with increased lung vascular permeability.ConclusionsWe demonstrate that mitogen-activated protein kinase pathways mediate inflammatory lung injury during ventilator-induced lung injury. C-Jun-NH(2)-terminal kinase was also involved in alveolo-capillary leakage and edema formation, whereas MMP8 inhibited alveolo-capillary protein leakage."xsd:string |
| http://purl.uniprot.org/citations/18270588 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0001601"xsd:string |
| http://purl.uniprot.org/citations/18270588 | http://purl.uniprot.org/core/author | "Wu W."xsd:string |
| http://purl.uniprot.org/citations/18270588 | http://purl.uniprot.org/core/author | "Watkins S.C."xsd:string |
| http://purl.uniprot.org/citations/18270588 | http://purl.uniprot.org/core/author | "Kaminski N."xsd:string |
| http://purl.uniprot.org/citations/18270588 | http://purl.uniprot.org/core/author | "Choi A.M."xsd:string |
| http://purl.uniprot.org/citations/18270588 | http://purl.uniprot.org/core/author | "Ryter S.W."xsd:string |
| http://purl.uniprot.org/citations/18270588 | http://purl.uniprot.org/core/author | "Ifedigbo E."xsd:string |
| http://purl.uniprot.org/citations/18270588 | http://purl.uniprot.org/core/author | "Hoetzel A."xsd:string |
| http://purl.uniprot.org/citations/18270588 | http://purl.uniprot.org/core/author | "Dolinay T."xsd:string |
| http://purl.uniprot.org/citations/18270588 | http://purl.uniprot.org/core/author | "Kaynar A.M."xsd:string |
| http://purl.uniprot.org/citations/18270588 | http://purl.uniprot.org/core/author | "Szilasi M."xsd:string |
| http://purl.uniprot.org/citations/18270588 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18270588 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/18270588 | http://purl.uniprot.org/core/pages | "e1601"xsd:string |
| http://purl.uniprot.org/citations/18270588 | http://purl.uniprot.org/core/title | "Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury."xsd:string |
| http://purl.uniprot.org/citations/18270588 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/18270588 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18270588 |
| http://purl.uniprot.org/citations/18270588 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18270588 |
| http://purl.uniprot.org/uniprot/#_D3Z1Z4-mappedCitation-18270588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18270588 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1Q6-mappedCitation-18270588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18270588 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPL3-mappedCitation-18270588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18270588 |
| http://purl.uniprot.org/uniprot/#_A3KBF5-mappedCitation-18270588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18270588 |
| http://purl.uniprot.org/uniprot/#_A6P3E4-mappedCitation-18270588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18270588 |