| http://purl.uniprot.org/citations/1827068 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1827068 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1827068 | http://www.w3.org/2000/01/rdf-schema#comment | "In addition to its role in the recognition of foreign antigens, the T cell receptor (TCR) alpha gene serves as a model system for studies of developmentally-regulated, lineage-specific gene expression in T cells. TCR alpha gene expression is restricted to cells of the TCR alpha/beta+ lineage, and is controlled by a T cell-specific transcriptional enhancer located 4.5 kb 3' to the C alpha gene segment. The TCR alpha enhancer contains four nuclear protein binding sites called T alpha 1-T alpha 4. In this report we describe the identification and characterization of a novel human cDNA, hGATA-3 that binds to the T alpha 3 element of the human TCR alpha enhancer. hGATA-3 contains a zinc finger domain that is highly related to the DNA-binding domain of the erythroid-specific transcription factor, GATA-1, and binds to a region of T alpha 3 that contains a consensus GATA binding site (AGATAG). Northern blot analyses of hematopoietic cell lines demonstrate that hGATA-3 is expressed exclusively in T cells. Overexpression of hGATA-3 in HeLa cells or human B cells specifically activated transcription from a co-transfected reporter plasmid containing two copies of the T alpha 3 binding site located upstream of the minimal SV40 promoter. Taken together these results demonstrate that hGATA-3 is a novel lineage-specific hematopoietic transcription factor that appears to play an important role in regulating the T cell-specific expression of the TCR alpha gene."xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1991.tb08059.x"xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1991.tb08059.x"xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/author | "Tsai S.-F."xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/author | "Tsai S.-F."xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/author | "Leiden J.M."xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/author | "Leiden J.M."xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/author | "Orkin S.H."xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/author | "Orkin S.H."xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/author | "Ho I.-C."xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/author | "Ho I.-C."xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/author | "Marin N."xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/author | "Marin N."xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/author | "Oakley B.K."xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/author | "Oakley B.K."xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/author | "Vorhees P."xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/author | "Vorhees P."xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/pages | "1187-1192"xsd:string |
| http://purl.uniprot.org/citations/1827068 | http://purl.uniprot.org/core/pages | "1187-1192"xsd:string |