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http://purl.uniprot.org/citations/18272866http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18272866http://www.w3.org/2000/01/rdf-schema#comment"

Background

Individuals with high levels of antibodies to the Epstein-Barr virus nuclear antigen 1 (EBNA-1) have an increased risk of developing multiple sclerosis (MS), but this association could be confounded by genetic susceptibility.

Methods

We conducted a nested case-control study including 148 women with MS (18 with blood collected before disease onset) and 296 age-matched healthy women to determine whether the human leukocyte antigen (HLA) DRB1*1501 allele (DR15) and anti-Epstein-Barr virus (anti-EBV) antibody titers are independent risk factors for MS.

Results

The association between anti-EBNA-1 antibody titers and MS risk was not affected by adjustment for DR15 and was similar in DR15-positive and DR15-negative women. The relative risk of MS among DR15-positive women with elevated (>1:320) anti-EBNA-1 titers was ninefold higher than that of DR15-negative women with low (<1:80) anti-EBNA-1 titers.

Conclusions

Anti-Epstein-Barr virus nuclear antigen 1 (anti-EBNA-1) antibody titers are a risk factor for multiple sclerosis (MS), independently from the DR15 allele. Carriers of the DR15 allele with elevated anti-EBNA-1 antibody titers may have a markedly increased risk of MS."xsd:string
http://purl.uniprot.org/citations/18272866http://purl.org/dc/terms/identifier"doi:10.1212/01.wnl.0000294325.63006.f8"xsd:string
http://purl.uniprot.org/citations/18272866http://purl.uniprot.org/core/author"Rioux J.D."xsd:string
http://purl.uniprot.org/citations/18272866http://purl.uniprot.org/core/author"De Jager P.L."xsd:string
http://purl.uniprot.org/citations/18272866http://purl.uniprot.org/core/author"Hafler D.A."xsd:string
http://purl.uniprot.org/citations/18272866http://purl.uniprot.org/core/author"Ascherio A."xsd:string
http://purl.uniprot.org/citations/18272866http://purl.uniprot.org/core/author"Munger K.L."xsd:string
http://purl.uniprot.org/citations/18272866http://purl.uniprot.org/core/author"Simon K.C."xsd:string
http://purl.uniprot.org/citations/18272866http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18272866http://purl.uniprot.org/core/name"Neurology"xsd:string
http://purl.uniprot.org/citations/18272866http://purl.uniprot.org/core/pages"1113-1118"xsd:string
http://purl.uniprot.org/citations/18272866http://purl.uniprot.org/core/title"Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis."xsd:string
http://purl.uniprot.org/citations/18272866http://purl.uniprot.org/core/volume"70"xsd:string
http://purl.uniprot.org/citations/18272866http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18272866
http://purl.uniprot.org/citations/18272866http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18272866
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