http://purl.uniprot.org/citations/18273032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/18273032 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveHuman leukocyte antigen DQ (HLA-DQ) genetic factors and islet autoantibodies are strongly associated with type 1 diabetes (T1D) and are currently used to predict T1D. This study examined whether islet autoantibodies in the cord blood of newborns to nondiabetic mothers were associated with the (T1D) high-risk genotype HLA-DQ2/8, gestational infections or both.Study designCord blood samples were taken from 33 683 newborns and used for HLA typing and analyses of islet autoantibodies. Parents completed questionnaires when the child was 2 months of age.ResultThe prevalence of newborn islet autoantibodies consistently varied with season over 4 years (P<0.0001); lowest in first quarter (1.2%) and highest in third (2.4%). Cord blood islet autoantibodies were associated with HLA-DQ2/8 in the second (OR, 2.30; P=0.02), third (OR, 2.12; P=0.008) and fourth quarters (OR, 2.49; P=0.007), but not in the first (OR, 1.13). Reported gastroenteritis was additionally associated with islet autoantibodies in the third quarter (OR, 1.80, P=0.04).ConclusionAn association between HLA and islet autoimmunity may depend on environmental exposure during pregnancy. Follow-up of mothers and children will determine risk of T1D."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.jp.7211912"xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Larsson K."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Jonsson B."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Nilsson A."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Carlsson A."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Kockum K."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Almgren P."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Lindberg B."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Lernmark A."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Ivarsson S.A."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Gustavsson B."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Cilio C.M."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Hansson I."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Hansson G."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Larsson H.E."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Lernmark B."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Neiderud J."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Sjoblad S."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Buveris-Svendburg B."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Cederwall E."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Heins J."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Lindehammer S."xsd:string |
http://purl.uniprot.org/citations/18273032 | http://purl.uniprot.org/core/author | "Lynch K.F."xsd:string |