| http://purl.uniprot.org/citations/18275829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18275829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18275829 | http://www.w3.org/2000/01/rdf-schema#comment | "Immunodominant and public T cell receptor (TCR) usage is relatively common in many viral diseases yet surprising in the context of the large naive TCR repertoire. We examined the highly conserved Vbeta17:Valpha10.2 JM22 T cell response to the influenza matrix peptide (58-66)-HLA-A*0201 (HLA-A2-flu) through extensive kinetic, thermodynamic, and structural analyses. We found several conformational adjustments that accompany JM22-HLA-A2-flu binding and identified a binding "hotspot" within the Vbeta domain of the TCR. Within this hotspot, key germline-encoded CDR1 and CDR2 loop residues and a crucial but commonly coded residue in the hypervariable region of CDR3 provide the basis for the substantial bias in the selection of the germline-encoded Vbeta17 domain. The chances of having a substantial number of T cells in the naive repertoire that have HLA-A2-flu-specific Vbeta17 receptors may consequently be relatively high, thus explaining the immunodominant usage of this clonotype."xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2007.12.018"xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2007.12.018"xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/author | "Bell J.I."xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/author | "Bell J.I."xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/author | "Jones E.Y."xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/author | "Jones E.Y."xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/author | "McMichael A.J."xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/author | "McMichael A.J."xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/author | "Stewart-Jones G.B."xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/author | "Stewart-Jones G.B."xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/author | "Ishizuka J."xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/author | "Ishizuka J."xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/author | "van der Merwe A."xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/author | "van der Merwe A."xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/pages | "171-182"xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/pages | "171-182"xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/title | "The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain."xsd:string |
| http://purl.uniprot.org/citations/18275829 | http://purl.uniprot.org/core/title | "The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain."xsd:string |