| http://purl.uniprot.org/citations/18275834 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18275834 | http://www.w3.org/2000/01/rdf-schema#comment | "The initiation of cytotoxic immune responses requires the direct interaction between naive CD8+ T lymphocytes and dendritic cells (DCs). Multiphoton imaging in intact lymph nodes (LNs) showed that during priming, naive T cells and DCs establish sequentially brief (i.e., minutes) and long (hours) antigen-specific contacts. We show here that the expression of the Intercellular Adhesion Molecule-1 (ICAM-1) by mature DCs is critical for long-lasting contacts with CD8+ T cells but dispensable for short-lived antigen-specific interactions. Serial brief DC-T cell contacts induced early CD8+ T cell activation, proliferation, and differentiation into effector cytotoxic T lymphocytes in the first few days after immunization. ICAM-1-deficient mature DCs, however, failed to induce fully effective priming, because CD8+ T cells produced reduced amounts of interferon gamma and were clonally depleted after 2 weeks. In addition, Icam1(-/-) mice failed to respond to rechallenge. We conclude that ICAM-1-dependent long-lasting interactions between mature DCs and naive CD8+ T cells determine the survival of activated CD8+ T cells and the establishment of effective memory."xsd:string |
| http://purl.uniprot.org/citations/18275834 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2007.12.016"xsd:string |
| http://purl.uniprot.org/citations/18275834 | http://purl.uniprot.org/core/author | "Amigorena S."xsd:string |
| http://purl.uniprot.org/citations/18275834 | http://purl.uniprot.org/core/author | "Fetler L."xsd:string |
| http://purl.uniprot.org/citations/18275834 | http://purl.uniprot.org/core/author | "Scholer A."xsd:string |
| http://purl.uniprot.org/citations/18275834 | http://purl.uniprot.org/core/author | "Hugues S."xsd:string |
| http://purl.uniprot.org/citations/18275834 | http://purl.uniprot.org/core/author | "Boissonnas A."xsd:string |
| http://purl.uniprot.org/citations/18275834 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18275834 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/18275834 | http://purl.uniprot.org/core/pages | "258-270"xsd:string |
| http://purl.uniprot.org/citations/18275834 | http://purl.uniprot.org/core/title | "Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory."xsd:string |
| http://purl.uniprot.org/citations/18275834 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/18275834 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18275834 |
| http://purl.uniprot.org/citations/18275834 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18275834 |
| http://purl.uniprot.org/uniprot/#_P13597-mappedCitation-18275834 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18275834 |
| http://purl.uniprot.org/uniprot/#_Q3THH5-mappedCitation-18275834 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18275834 |
| http://purl.uniprot.org/uniprot/#_Q3U8M7-mappedCitation-18275834 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18275834 |
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| http://purl.uniprot.org/uniprot/#_Q3UDJ5-mappedCitation-18275834 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18275834 |
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| http://purl.uniprot.org/uniprot/#_Q3TB10-mappedCitation-18275834 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18275834 |
| http://purl.uniprot.org/uniprot/#_Q3TB21-mappedCitation-18275834 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18275834 |
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| http://purl.uniprot.org/uniprot/#_Q3U7T2-mappedCitation-18275834 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18275834 |